ENSIKLOPEDIA

Tekan Enter untuk memulai pencarian cepat.

Kembali ke Ensiklopedia Arsip Wikipedia Indonesia

Surufatinib

Chemical compound

Pharmaceutical compound

Surufatinib
Clinical data

Trade names	Sulanda
Other names	Sulfatinib; HMPL-012
ATC code	L01EX24 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name N-[2-(Dimethylamino)ethyl]-1-[3-[[4-[(2-methyl-1H-indol-5-yl)oxy]pyrimidin-2-yl]amino]phenyl]methanesulfonamide
CAS Number	1308672-74-3
PubChem CID	52920501
IUPHAR/BPS	9769
DrugBank	DB15106
ChemSpider	57583328
UNII	B2K5L1L8S9
ChEMBL	ChEMBL4297190
Chemical and physical data
Formula	C₂₄H₂₈N₆O₃S
Molar mass	480.59 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C
InChI InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29) Key:TTZSNFLLYPYKIL-UHFFFAOYSA-N

Surufatinib (trade name Sulanda) is pharmaceutical drug for the treatment of cancer. In China, it is approved for late-stage, well-differentiated, extrapancreatic neuroendocrine tumors.^[1]

It is also under investigation for the treatment of other types of solid tumors.^[2]^[3]

Surufatinib targets fibroblast growth factor receptor 1 (FGFR1).^[4]

References

↑ Syed YY (April 2021). "Surufatinib: First Approval". Drugs. 81 (6): 727–732. doi:10.1007/s40265-021-01489-y. PMID 33788183.
↑ Liao S, Li J, Gao S, Han Y, Han X, Wu Y, et al. (2023). "Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1-3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment". Frontiers in Oncology. 13 1158857. doi:10.3389/fonc.2023.1158857. PMC 10286821. PMID 37361567.
↑ Xu JM, Wang Y, Chen YL, Jia R, Shen L, Wang J, et al. (2014). "First-in-human (FIH) phase I study of a selective VEGFR/FGFR dual inhibitor sulfatinib with milled formulation in patients with advanced solid tumors". Journal of Clinical Oncology. 32 (15_suppl): 2615. doi:10.1200/jco.2014.32.15_suppl.2615.
↑ Lin Q, Dai S, Qu L, Lin H, Guo M, Wei H, et al. (January 2024). "Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R". Communications Chemistry. 7 (1) 3. Bibcode:2024CmChe...7....3L. doi:10.1038/s42004-023-01084-0. PMC 10764862. PMID 38172256.

v
t
e

Targeted cancer therapy / antineoplastic agents (L01)

CI monoclonal antibodies ("-mab")

Receptor tyrosine kinase	ErbB: HER1/EGFR (Cetuximab Panitumumab) HER2/neu (Pertuzumab Trastuzumab (+hyaluronidase) Trastuzumab emtansine Trastuzumab deruxtecan Zanidatamab )
Others for solid tumors	EpCAM (Catumaxomab Edrecolomab) VEGF-A (Bevacizumab)
Leukemia/lymphoma	lymphoid: CD3 (Glofitamab, Elranatamab, Mosunetuzumab), CD20 (Glofitamab Ibritumomab Mosunetuzumab Obinutuzumab Ofatumumab Rituximab Tositumomab), CD30 (Brentuximab), CD52 (Alemtuzumab) myeloid: CD33 (Gemtuzumab ozogamicin)
Other	Amivantamab (+hyaluronidase) Atezolizumab (+hyaluronidase) Avelumab Axatilimab Belantamab mafodotin Bermekimab Blinatumomab Cemiplimab Cosibelimab Daratumumab Dinutuximab beta Dostarlimab Durvalumab Elotuzumab Enfortumab vedotin Epcoritamab Inotuzumab ozogamicin Ipilimumab Isatuximab Linvoseltamab Loncastuximab tesirine Mirvetuximab soravtansine Mogamulizumab Moxetumomab pasudotox Naxitamab Necitumumab Nivolumab (+hyaluronidase, +relatlimab) Olaratumab Oportuzumab monatox Pembrolizumab (+berahyaluronidase alfa) Penpulimab Polatuzumab vedotin Prolgolimab Ramucirumab Retifanlimab Sabatolimab Sacituzumab govitecan Serplulimab Sugemalimab Tafasitamab Talquetamab Tarlatamab Teclistamab Tislelizumab Tisotumab vedotin Toripalimab Tremelimumab Zenocutuzumab Zolbetuximab

Tyrosine kinase inhibitors ("-nib")

Receptor tyrosine kinase

ErbB: HER1/EGFR (Afatinib
Aumolertinib
Brigatinib
Dacomitinib
Erlotinib
Gefitinib
Icotinib
Lazertinib
Mobocertinib
Olmutinib
Osimertinib
Rociletinib
Sevabertinib
Sunvozertinib
Vandetanib)

HER1/EGFR and HER2/neu

BRAF

RTK class III: C-kit and PDGFR (Avapritinib
Axitinib
Masitinib
Pazopanib
Ripretinib
Sorafenib
Sunitinib
Toceranib)
FLT3 (Lestaurtinib, Gilteritinib (AXL, ALK, LTK))

VEGFR
- Axitinib
- Cediranib
- Fruquintinib
- Lenvatinib
- Nintedanib
- Pazopanib
- Regorafenib
- Semaxanib
- Sorafenib
- Sunitinib
- Tivozanib
- Toceranib
- Vandetanib

ALK

RET inhibitors: Entrectinib (ALK, ROS1, NTRK), Futibatinib (FGFR2), Infigratinib, Larotrectinib (NTRK), Pemigatinib (FGFR), Pralsetinib, Repotrectinib (ROS1, TRK, ALK), Selpercatinib (VEGFR, FGFR), Taletrectinib (ROS1), Vandetanib (VEGFR, EGFR).

c-MET inhibitors: Cabozantinib (VEGFR), Capmatinib, Crizotinib (ALK)

Non-receptor

bcr-abl
- Asciminib
- Bosutinib
- Dasatinib
- Imatinib
- Nilotinib
- Ponatinib
- Radotinib

Src (Bosutinib
Dasatinib)

Janus kinase (JAK)

MAP2K (MEK)

EML4-ALK

Bruton's (BTK)

Other

fusion protein against VEGF (Aflibercept)

proapoptotic peptide against ANXA2 and prohibitin (Adipotide)

exotoxin against IL-2 (Denileukin diftitox)

mTOR inhibitors

hedgehog inhibitors

CDK inhibitors

KRAS inhibitors
- Adagrasib
- Sotorasib

Pi3K inhibitors

Menin inhibitors
- Revumenib
- Ziftomenib

Fibroblast growth factor receptor (FGFR) inhibitors
Erdafitinib
Futibatinib
Infigratinib
Pemigatinib

Avapritinib
Cabozantinib
Capivasertib
Capmatinib
Defactinib (+avutometinib)
Entrectinib
Gilteritinib
Larotrectinib
Lenvatinib
Masitinib
Midostaurin
Nintedanib
Odronextamab
Pazopanib
Pexidartinib
Pralsetinib
Quizartinib
Regorafenib
Repotrectinib
Ripretinib
Selpercatinib
Sitravatinib
Sorafenib
Sunitinib
Surufatinib
Tebentafusp
Tepotinib
Toceranib
Tunlametinib
Umbralisib
Vandetanib
Venetoclax
Vimseltinib

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by adding missing information.

v
t
e

Sumber data: id.wikipedia.org via REST API v1