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Kembali ke Ensiklopedia Arsip Wikipedia Indonesia Funapide FunapideAnalgesic drug under development Pharmaceutical compoundFunapideClinical dataRoutes ofadministrationBy mouth, topicalATC codeNoneIdentifiers IUPAC name (7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one CAS Number1259933-16-8 YPubChem CID49836093ChemSpider34500834UNIIA5595LHJ2LKEGGD11156Chemical and physical dataFormulaC22H14F3NO5Molar mass429.351 g·mol−13D model (JSmol)Interactive image SMILES C1C2(C3=CC=CC=C3N(C2=O)CC4=CC=C(O4)C(F)(F)F)C5=CC6=C(C=C5O1)OCO6 InChI InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m0/s1Key:NEBUOXBYNAHKFV-NRFANRHFSA-N Funapide (INN; former developmental codes TV-45070 and XEN402) is a novel analgesic under development by Xenon Pharmaceuticals (formerly in partnership with Teva Pharmaceutical Industries) for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain.[1][2][3][4] It acts as a small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker.[1][2][4] Funapide was evaluated in humans in both oral and topical formulations, and as of July 2014, had reached phase IIb clinical trials.[1][3] Development of the drug was discontinued in 2022.[5] See also List of investigational analgesics References 1 2 3 Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (August 2014). "Recent progress in sodium channel modulators for pain". Bioorganic & Medicinal Chemistry Letters. 24 (16): 3690–3699. doi:10.1016/j.bmcl.2014.06.038. PMID 25060923. 1 2 Ali Z, Palmer JE, Goli V (2013). "Anticonvulsants: Clinical". In McMahon S, Koltzenburg M, Tracey I, Turk DC (eds.). Wall & Melzack's Textbook of Pain (6 ed.). Elsevier Health Sciences. p. 508. ISBN 978-0-7020-4059-7. OCLC 1008841684. 1 2 "TV-45070: A Small Molecule for the Treatment of the Orphan Disease EM and Other Pain Disorders". Xenon Pharma. Archived from the original on 15 July 2013. 1 2 "Teva and Xenon Announce Teva's World Wide License of Xenon's Pain Drug XEN402". Xenon Pharma. 11 December 2012. Archived from the original on 26 July 2014. Retrieved 2014-07-20. ↑ "Funapide - Flexion Therapeutics". AdisInsight. Springer Nature Switzerland AG. vteAnalgesics (N02A, N02B)OpioidsOpiates/opium Codeine# +aspirin +paracetamol Morphine# (+naltrexone) Opium Laudanum Paregoric Semisynthetic Acetyldihydrocodeine Benzylmorphine Buprenorphine (+naloxone) Butorphanol Desomorphine Dihydrocodeine (+paracetamol) Dihydromorphine Etorphine Ethylmorphine Hydrocodone (+paracetamol, +ibuprofen, +aspirin) Hydromorphinol Hydromorphone Levorphanol Metopon Nalbuphine Nicocodeine Nicodicodine Nicomorphine Oxycodone (+paracetamol, +aspirin, +ibuprofen, +naloxone, +naltrexone) Oxymorphone Papaveretum Thebacon Synthetic Alfentanil Alphaprodine Anileridine Bezitramide Carfentanil Dextromoramide Dextropropoxyphene Dezocine Dimenoxadol Dipipanone Ethoheptazine Fentanyl# (+fluanisone) Ketobemidone Lofentanil Meptazinol Methadone# NFEPP Norpipanone Oliceridine Pentazocine Pethidine (meperidine) Phenadoxone Phenazocine Phenoperidine Piminodine Piritramide Proheptazine Propiram Remifentanil Sufentanil Tapentadol Tegileridine Tilidine Tramadol (+celecoxib, +paracetamol) Viminol Paracetamol-type Acetanilide‡ Bucetin‡ Butacetin‡ Paracetamol (acetaminophen)# +aspirin/caffeine +butalbital +codeine +hydrocodone +ibuprofen +metoclopramide +oxycodone +propyphenazone/caffeine +tramadol Parapropamol‡ Phenacetin‡ Propacetamol‡ NSAIDsPropionates Benoxaprofen ‡ Fenoprofen Flurbiprofen Ibuprofen# (Dexibuprofen) (+paracetamol) Ketoprofen (Dexketoprofen) Loxoprofen Naproxen Oxaprozin Suprofen Tiaprofenic acid Zaltoprofen Oxicams Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam Acetates Acemetacin Bromfenac Diclofenac Etodolac Indometacin (Indometacin farnesil) Ketorolac Sulindac Tolmetin Zomepirac ‡ COX-2 inhibitors Celecoxib (+tramadol) Etoricoxib Lumiracoxib ‡ Parecoxib Rofecoxib ‡ Valdecoxib ‡ Fenamates Flufenamic acid Meclofenamic acid Mefenamic acid Tolfenamic acid Salicylates Aspirin (acetylsalicylic acid)# (+paracetamol/caffeine) Aloxiprin Benorylate Carbasalate calcium Choline salicylate Diflunisal Dipyrocetyl Ethenzamide Guacetisal Imidazole salicylate Magnesium salicylate Morpholine salicylate Potassium salicylate Salicin Salicylamide Salsalate Sodium salicylate Wintergreen (methyl salicylate) Pyrazolones Aminophenazone‡ Ampyrone Metamizole (dipyrone) Nifenazone Phenazone Propyphenazone (+paracetamol/caffeine) Others Benzydamine Floctafenine Glafenine Nabumetone Nimesulide Proquazone Cannabinoids Cannabidiol Cannabis Nabilone Nabiximols Tetrahydrocannabinol (dronabinol) Ion channelmodulatorsCalcium blockers Alcohol (ethanol) Gabapentin Gabapentin enacarbil Leconotide Mirogabalin Pregabalin Ziconotide Sodium blockers Carbamazepine Lacosamide Local anesthetics (e.g., cocaine, lidocaine) Mexiletine Nefopam Tricyclic antidepressants (e.g., amitriptyline#) Nav1.7/1.8-selective: DSP-2230§ Funapide§ PF-05089771§ Suzetrigine Potassium openers Flupirtine‡ Myorelaxants Carisoprodol Chlorzoxazone Cyclobenzaprine Mephenoxalone Methocarbamol Orphenadrine Others Analgecine Analgesic adjuvant Bedinvetmab Camphor Capsaicin Clonidine Frunevetmab Izenivetmab Ketamine Menthol Methoxyflurane Phenazopyridine Proglumide Relfovetmab Rimazolium Tanezumab #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III vteLocal anesthetics (primarily sodium channel blockers) (N01B)Esters by acidAminobenzoic Benzocaine Benzonatate Butacaine Butamben Chloroprocaine Dimethocaine Lucaine Meprylcaine Metabutethamine Metabutoxycaine Nitracaine Orthocaine Propoxycaine Procaine (Novocaine) Proxymetacaine Risocaine Tetracaine Benzoic Amylocaine Cocaine Cyclomethycaine α-Eucaine β-Eucaine Hexylcaine Isobucaine Piperocaine ArCO2- (not para-amino or Ph) Amoproxan (3,4,5-Trimethoxybenzoyl) 3-(p-Fluorobenzoyloxy)tropane Amides Articaine Bupivacaine#/Levobupivacaine/Ropivacaine Butanilicaine Carticaine Cinchocaine (Dibucaine) Etidocaine Lidocaine# Mepivacaine Prilocaine Trimecaine Combinations Anesthetic/vasoconstrictor Bupivacaine/meloxicam Lidocaine/prilocaine TAC Iontocaine #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III vteIon channel modulatorsCalciumVDCCsTooltip Voltage-dependent calcium channelsBlockers L-type-selective: Dihydropyridines: Amlodipine (+telmisartan and indapamide) Aranidipine Azelnidipine Barnidipine Clevidipine Cronidipine Darodipine Dexniguldipine Elgodipine Elnadipine Felodipine Flordipine Furnidipine Iganidipine Isradipine Lacidipine Lemildipine Lercanidipine Levamlodipine Levniguldipine Manidipine Mepirodipine Mesudipine Nicardipine Nifedipine Niguldipine Niludipine Nilvadipine Nimodipine Nisoldipine Nitrendipine Olradipine Oxodipine Palonidipine Pranidipine Ryodipine (riodipine) Sagandipine Sornidipine Teludipine Tiamdipine Trombodipine Vatanidipine; Diltiazem derivatives: Clentiazem Diltiazem Iprotiazem Nictiazem Siratiazem; Phenylalkylamines: Anipamil Dagapamil Devapamil Dexverapamil Emopamil Etripamil Falipamil Gallopamil Levemopamil Nexopamil Norverapamil Ronipamil Tiapamil Verapamil; Others: AH-1058 Brinazarone Budiodarone Celivarone Cyproheptadine Dronedarone Fantofarone SR-33805 Tetrahydropalmatine N-type-selective: ω-Conotoxins ω-Conotoxin GVIA Caroverine Huwentoxin XVI Leconotide (ω-conotoxin CVID) PD-173212 Ralfinamide Safinamide Z160 Ziconotide (ω-conotoxin MVIIA) P-type-selective: ω-Agatoxin IVA ω-Agatoxin IVB R-type-selective: SNX-482 T-type-selective: ABT-639 ML-218 Niflumic acid NNC 55-0396 ProTx I Z944 Zonisamide Non-selective: ω-Agatoxin TK ω-Conotoxin MVIIC Benidipine Bepridil Cilnidipine Cinnarizine Dotarizine Efonidipine Flunarizine Lamotrigine Levetiracetam Lomerizine Loperamide Mibefradil NP078585 Ruthenium red TROX-1 α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin Mirogabalin PD-200,347 PD-217,014 PD-299,685 Phenibut Pregabalin Others/unsorted: Bencyclane Berbamine Bevantolol Canadine Carboxyamidotriazole Cycleanine Dauricine Dimeditiapramine Diproteverine Enpiperate Eperisone Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil Ochratoxin A Osthol Otilonium bromide Paramethadione Phensuximide Pinaverium bromide Prenylamine Rhynchophylline Sesamodil Silperisone Sipatrigine Terodiline Tetrandrine Tolperisone Trimethadione Valperinol Activators L-type-selective: Bay K8644 PotassiumVGKCsTooltip Voltage-gated potassium channelsBlockers 3,4-Diaminopyridine (amifampridine) 4-Aminopyridine (fampridine/dalfampridine) Adekalant Almokalant Amiodarone Azimilide Bretylium Bunaftine Charybdotoxin Clamikalant Conotoxins Dalazatide Dendrotoxin Dofetilide Dronedarone E-4031 Hanatoxin HgeTx1 HsTx1 Ibutilide Inakalant Kaliotoxin Linopirdine Lolitrem B Maurotoxin Nifekalant Notoxin Paxilline Pinokalant Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid AZD1305 Azimilide Bedaquiline BeKm-1 BmTx3 BRL-32872 Chlorpromazine Cisapride Clarithromycin Darifenacin Dextropropoxyphene Diallyl trisulfide Domperidone E-4031 Ergtoxins Erythromycin Gigactonine Haloperidol Ketoconazole Norpropoxyphene Orphenadrine Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine Vanoxerine Vernakalant KCNQ (Kv7)-specific: Linopirdine XE-991 Spooky toxin (SsTx) Activators KCNQ (Kv7)-specific: Flupirtine Retigabine IRKsTooltip Inwardly rectifying potassium channelBlockers KATPTooltip ATP-sensitive potassium channel-specific: Acetohexamide Carbutamide Chlorpropamide Glibenclamide (glyburide) Glibornuride Glicaramide Gliclazide Glimepiride Glipizide Gliquidone Glisoxepide Glyclopyramide Glycyclamide Metahexamide Mitiglinide Nateglinide Repaglinide Tolazamide Tolbutamide GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: Barium Caramiphen Cloperastine Clozapine Dextromethorphan Ethosuximide Ifenprodil Tertiapin Tipepidine Activators KATPTooltip ATP-sensitive potassium channel-specific: Aprikalim Bimakalim Cromakalim Diazoxide Emakalim Levcromakalim Mazokalim Minoxidil Minoxidil sulfate Naminidil Nicorandil Pinacidil Rilmakalim Sarakalim GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810) KCaTooltip Calcium-activated potassium channelBlockers BKCa-specific: Ethanol (alcohol) GAL-021 Activators BKCa-specific: Flufenamic acid Meclofenamic acid Niflumic acid Nimesulide Rottlerin (mallotoxin) Tolfenamic acid K2PsTooltip Tandem pore domain potassium channelBlockers 12-O-Tetradecanoylphorbol-13-acetate Arachidonic acid Fluoxetine Norfluoxetine Activators Riluzole SodiumVGSCsTooltip Voltage-gated sodium channelsBlockers Antianginals: Ranolazine Antiarrhythmics (class I): Ajmaline Aprindine Disopyramide Dronedarone Encainide Flecainide Lidocaine Lorajmine Lorcainide Mexiletine Moricizine Pilsicainide Prajmaline Procainamide Propafenone Quinidine Sparteine Tocainide Anticonvulsants: Acetylpheneturide Carbamazepine Cenobamate Chlorphenacemide Elpetrigine Eslicarbazepine acetate Ethotoin Fosphenytoin Lamotrigine Lacosamide Licarbazepine Mephenytoin Oxcarbazepine Oxitriptyline Phenacemide Pheneturide Phenytoin Rufinamide Sipatrigine Topiramate Sodium valproate Valnoctamide Valproate pivoxil Valproate semisodium Valproic acid Valpromide Zonisamide Local anesthetics: pFBT Amylocaine Articaine Benzocaine Bupivacaine (Levobupivacaine, Ropivacaine) Butacaine Butamben Chloroprocaine Cinchocaine Cocaine Cyclomethycaine Dimethocaine Diphenhydramine Etidocaine Hexylcaine Iontocaine Lidocaine Mepivacaine Meprylcaine Metabutoxycaine Orthocaine Piperocaine Prilocaine Procaine Propoxycaine Proxymetacaine Risocaine Tetracaine Trimecaine Analgesics: AZD-3161 DSP-2230 Funapide GDC-0276 NKTR-171 PF-04531083 PF-05089771 Ralfinamide Raxatrigine RG7893 (GDC-0287) Suzetrigine Toxins: Conotoxins Neosaxitoxin Saxitoxin Tetrodotoxin Zetekitoxin AB Others: Buprenorphine Evenamide Menthol (mint) Safinamide Tricyclic antidepressants Activators Aconitine Atracotoxins (ω-Atracotoxin, Robustoxin, Versutoxin) Batrachotoxin Ciguatoxins Grayanotoxins Poneratoxin ENaCTooltip Epithelial sodium channelBlockers Amiloride Benzamil Triamterene Activators Solnatide ASICsTooltip Acid-sensing ion channelBlockers A-317567 Amiloride Aspirin Ibuprofen PcTX1 ChlorideCaCCsTooltip Calcium-activated chloride channelBlockers Crofelemer DIDS Ethacrynic acid Flufenamic acid Fluoxetine Furosemide Glibenclamide Mefloquine Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulatorBlockers Glibenclamide Lonidamine Piretanide Activators 1,7-Phenanthroline 1,10-Phenanthroline 4,7-Phenanthroline 7,8-Benzoquinoline Ivacaftor Phenanthridine UnsortedBlockers Bumetanide Flufenamic acid Meclofenamic acid Mefenamic acid Mepacrine Niflumic acid Talniflumate Tolfenamic acid Trifluoperazine OthersTRPsTooltip Transient receptor potential channels See here instead. LGICsTooltip Ligand gated ion channels See here instead. See also: Receptor/signaling modulators • Transient receptor potential channel modulators This analgesic-related article is a stub. You can help Wikipedia by adding missing information.vte
