ENSIKLOPEDIA Cari Tekan Enter untuk memulai pencarian cepat. Kembali ke Ensiklopedia Arsip Wikipedia Indonesia Bunaftine BunaftineChemical compound Pharmaceutical compoundBunaftineClinical dataATC codeC01BD03 (WHO) Identifiers IUPAC name N-[2-(Diethylamino)ethyl]-N-propylnaphthalene-1-carboxamide CAS Number32421-46-8 YPubChem CID36131ChemSpider33233 YUNIIGH09PRQ3FUKEGGD07428 YChEMBLChEMBL2104200CompTox Dashboard (EPA)DTXSID90186165 ECHA InfoCard100.046.373 Chemical and physical dataFormulaC21H30N2OMolar mass326.484 g·mol−13D model (JSmol)Interactive image SMILES O=C(N(CCCC)CCN(CC)CC)c2cccc1ccccc12 InChI InChI=1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3 YKey:WWGZXRYELYWJBD-UHFFFAOYSA-N Y (verify) Bunaftine (or bunaphtine[1]) is an antiarrhythmic agent.[2] It is classified in class III.[3] References ↑ Tamargo J (August 1980). "Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers". Arch Int Pharmacodyn Ther. 246 (2): 224–36. PMID 7436628. ↑ Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M (May 1983). "Intropic effects of several antiarrhythmic drugs". Jpn Heart J. 24 (3): 377–90. doi:10.1536/ihj.24.377. PMID 6876382. ↑ Fenici R, Marchei M, Bellocci F, Zecchi P (July 1977). "Effect of bunaphtine on right atrial repolarisation in man". Br Heart J. 39 (7): 787–94. doi:10.1136/hrt.39.7.787. PMC 483317. PMID 328029. vteIon channel modulatorsCalciumVDCCsTooltip Voltage-dependent calcium channelsBlockers L-type-selective: Dihydropyridines: Amlodipine (+telmisartan and indapamide) Aranidipine Azelnidipine Barnidipine Clevidipine Cronidipine Darodipine Dexniguldipine Elgodipine Elnadipine Felodipine Flordipine Furnidipine Iganidipine Isradipine Lacidipine Lemildipine Lercanidipine Levamlodipine Levniguldipine Manidipine Mepirodipine Mesudipine Nicardipine Nifedipine Niguldipine Niludipine Nilvadipine Nimodipine Nisoldipine Nitrendipine Olradipine Oxodipine Palonidipine Pranidipine Ryodipine (riodipine) Sagandipine Sornidipine Teludipine Tiamdipine Trombodipine Vatanidipine; Diltiazem derivatives: Clentiazem Diltiazem Iprotiazem Nictiazem Siratiazem; Phenylalkylamines: Anipamil Dagapamil Devapamil Dexverapamil Emopamil Etripamil Falipamil Gallopamil Levemopamil Nexopamil Norverapamil Ronipamil Tiapamil Verapamil; Others: AH-1058 Brinazarone Budiodarone Celivarone Cyproheptadine Dronedarone Fantofarone SR-33805 Tetrahydropalmatine N-type-selective: ω-Conotoxins ω-Conotoxin GVIA Caroverine Huwentoxin XVI Leconotide (ω-conotoxin CVID) PD-173212 Ralfinamide Safinamide Z160 Ziconotide (ω-conotoxin MVIIA) P-type-selective: ω-Agatoxin IVA ω-Agatoxin IVB R-type-selective: SNX-482 T-type-selective: ABT-639 ML-218 Niflumic acid NNC 55-0396 ProTx I Z944 Zonisamide Non-selective: ω-Agatoxin TK ω-Conotoxin MVIIC Benidipine Bepridil Cilnidipine Cinnarizine Dotarizine Efonidipine Flunarizine Lamotrigine Levetiracetam Lomerizine Loperamide Mibefradil NP078585 Ruthenium red TROX-1 α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin Mirogabalin PD-200,347 PD-217,014 PD-299,685 Phenibut Pregabalin Others/unsorted: Bencyclane Berbamine Bevantolol Canadine Carboxyamidotriazole Cycleanine Dauricine Dimeditiapramine Diproteverine Enpiperate Eperisone Elpetrigine Ethadione Ethanol (alcohol) Ethosuximide Fasudil Fendiline Fostedil Imepitoin JTV-519 Lidoflazine Magnesium Manoalide Mesuximide Monatepil Naftopidil Ochratoxin A Osthol Otilonium bromide Paramethadione Phensuximide Pinaverium bromide Prenylamine Rhynchophylline Sesamodil Silperisone Sipatrigine Terodiline Tetrandrine Tolperisone Trimethadione Valperinol Activators L-type-selective: Bay K8644 PotassiumVGKCsTooltip Voltage-gated potassium channelsBlockers 3,4-Diaminopyridine (amifampridine) 4-Aminopyridine (fampridine/dalfampridine) Adekalant Almokalant Amiodarone Azimilide Bretylium Bunaftine Charybdotoxin Clamikalant Conotoxins Dalazatide Dendrotoxin Dofetilide Dronedarone E-4031 Hanatoxin HgeTx1 HsTx1 Ibutilide Inakalant Kaliotoxin Linopirdine Lolitrem B Maurotoxin Nifekalant Notoxin Paxilline Pinokalant Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid AZD1305 Azimilide Bedaquiline BeKm-1 BmTx3 BRL-32872 Chlorpromazine Cisapride Clarithromycin Darifenacin Dextropropoxyphene Diallyl trisulfide Domperidone E-4031 Ergtoxins Erythromycin Gigactonine Haloperidol Ketoconazole Norpropoxyphene Orphenadrine Pimozide PNU-282,987 Promethazine Quinidine Ranolazine Roxithromycin Sertindole Solifenacin Tamulotoxin Terodiline Terfenadine Thioridazine Tolterodine Vanoxerine Vernakalant KCNQ (Kv7)-specific: Linopirdine XE-991 Spooky toxin (SsTx) Activators KCNQ (Kv7)-specific: Flupirtine Retigabine IRKsTooltip Inwardly rectifying potassium channelBlockers KATPTooltip ATP-sensitive potassium channel-specific: Acetohexamide Carbutamide Chlorpropamide Glibenclamide (glyburide) Glibornuride Glicaramide Gliclazide Glimepiride Glipizide Gliquidone Glisoxepide Glyclopyramide Glycyclamide Metahexamide Mitiglinide Nateglinide Repaglinide Tolazamide Tolbutamide GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: Barium Caramiphen Cloperastine Clozapine Dextromethorphan Ethosuximide Ifenprodil Tertiapin Tipepidine Activators KATPTooltip ATP-sensitive potassium channel-specific: Aprikalim Bimakalim Cromakalim Diazoxide Emakalim Levcromakalim Mazokalim Minoxidil Minoxidil sulfate Naminidil Nicorandil Pinacidil Rilmakalim Sarakalim GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810) KCaTooltip Calcium-activated potassium channelBlockers BKCa-specific: Ethanol (alcohol) GAL-021 Activators BKCa-specific: Flufenamic acid Meclofenamic acid Niflumic acid Nimesulide Rottlerin (mallotoxin) Tolfenamic acid K2PsTooltip Tandem pore domain potassium channelBlockers 12-O-Tetradecanoylphorbol-13-acetate Arachidonic acid Fluoxetine Norfluoxetine Activators Riluzole SodiumVGSCsTooltip Voltage-gated sodium channelsBlockers Antianginals: Ranolazine Antiarrhythmics (class I): Ajmaline Aprindine Disopyramide Dronedarone Encainide Flecainide Lidocaine Lorajmine Lorcainide Mexiletine Moricizine Pilsicainide Prajmaline Procainamide Propafenone Quinidine Sparteine Tocainide Anticonvulsants: Acetylpheneturide Carbamazepine Cenobamate Chlorphenacemide Elpetrigine Eslicarbazepine acetate Ethotoin Fosphenytoin Lamotrigine Lacosamide Licarbazepine Mephenytoin Oxcarbazepine Oxitriptyline Phenacemide Pheneturide Phenytoin Rufinamide Sipatrigine Topiramate Sodium valproate Valnoctamide Valproate pivoxil Valproate semisodium Valproic acid Valpromide Zonisamide Local anesthetics: pFBT Amylocaine Articaine Benzocaine Bupivacaine (Levobupivacaine, Ropivacaine) Butacaine Butamben Chloroprocaine Cinchocaine Cocaine Cyclomethycaine Dimethocaine Diphenhydramine Etidocaine Hexylcaine Iontocaine Lidocaine Mepivacaine Meprylcaine Metabutoxycaine Orthocaine Piperocaine Prilocaine Procaine Propoxycaine Proxymetacaine Risocaine Tetracaine Trimecaine Analgesics: AZD-3161 DSP-2230 Funapide GDC-0276 NKTR-171 PF-04531083 PF-05089771 Ralfinamide Raxatrigine RG7893 (GDC-0287) Suzetrigine Toxins: Conotoxins Neosaxitoxin Saxitoxin Tetrodotoxin Zetekitoxin AB Others: Buprenorphine Evenamide Menthol (mint) Safinamide Tricyclic antidepressants Activators Aconitine Atracotoxins (ω-Atracotoxin, Robustoxin, Versutoxin) Batrachotoxin Ciguatoxins Grayanotoxins Poneratoxin ENaCTooltip Epithelial sodium channelBlockers Amiloride Benzamil Triamterene Activators Solnatide ASICsTooltip Acid-sensing ion channelBlockers A-317567 Amiloride Aspirin Ibuprofen PcTX1 ChlorideCaCCsTooltip Calcium-activated chloride channelBlockers Crofelemer DIDS Ethacrynic acid Flufenamic acid Fluoxetine Furosemide Glibenclamide Mefloquine Mibefradil Niflumic acid Activators Carbachol CFTRTooltip Cystic fibrosis transmembrane conductance regulatorBlockers Glibenclamide Lonidamine Piretanide Activators 1,7-Phenanthroline 1,10-Phenanthroline 4,7-Phenanthroline 7,8-Benzoquinoline Ivacaftor Phenanthridine UnsortedBlockers Bumetanide Flufenamic acid Meclofenamic acid Mefenamic acid Mepacrine Niflumic acid Talniflumate Tolfenamic acid Trifluoperazine OthersTRPsTooltip Transient receptor potential channels See here instead. LGICsTooltip Ligand gated ion channels See here instead. See also: Receptor/signaling modulators • Transient receptor potential channel modulators vteAntiarrhythmic agents (C01B)Channel blockersclass I(Na+ channel blockers)class Ia (Phase 0→ and Phase 3→) Ajmaline Disopyramide Hydroquinidine Lorajmine Prajmaline Procainamide# Quinidine# Sparteine class Ib (Phase 3←) IV Lidocaine# enteral Aprindine Mexiletine Tocainide class Ic (Phase 0→) Encainide‡ Ethacizine Flecainide Indecainide‡ Lorcainide Moracizine‡ Propafenone class III(Phase 3→, K+ channel blockers) Amiodarone Bretylium Bunaftine Celivarone† Dofetilide Dronedarone E-4031† Ibutilide Nifekalant Sotalol Tedisamil Vernakalant class IV(Phase 4→, Ca2+ channel blockers) Diltiazem Verapamil# Receptor agonistsand antagonistsclass II(Phase 4→, β blockers) Nadolol Pindolol Propranolol cardioselective Acebutolol Atenolol Esmolol Landiolol Metoprolol A1 agonist Adenosine Benzodiazepines Barbiturates M2 muscarinic antagonist: Atropine Disopyramide Quinidinemuscarinic agonist: Digoxin α receptors Amiodarone Bretylium Quinidine Verapamil Ion transportersNa+/ K+-ATPase Digitoxin Digoxin Ouabain #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by adding missing information.vte
