EPHB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJS, 2EAO, 3ZFX
Identifiers
Aliases	EPHB1, Ephb1, 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net, EPHT2, EPH receptor B1, ELK, NET
External IDs	OMIM: 600600; MGI: 1096337; HomoloGene: 20936; GeneCards: EPHB1; OMA:EPHB1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.2 Start 134,795,260 bp[1] End 135,260,467 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 101,799,327 bp[2] End 102,231,892 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell ganglionic eminence Brodmann area 23 secondary oocyte cerebellum cerebellar cortex ventricular zone cerebellar hemisphere primary visual cortex right hemisphere of cerebellum Top expressed in otic vesicle lumbar subsegment of spinal cord otolith organ utricle inferior colliculi substantia nigra deep cerebellar nuclei superior colliculus Rostral migratory stream medial ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity axon guidance receptor activity transmembrane-ephrin receptor activity protein-containing complex binding Cellular component integral component of membrane endosome cell projection early endosome membrane membrane integral component of plasma membrane extracellular region dendrite extracellular exosome endoplasmic reticulum cytosol plasma membrane axon cytoplasm filopodium tip membrane raft neuron projection receptor complex glutamatergic synapse Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway nervous system development dendritic spine development cell-substrate adhesion regulation of JNK cascade protein phosphorylation cell adhesion regulation of neuron death regulation of ERK1 and ERK2 cascade protein autophosphorylation peptidyl-tyrosine phosphorylation immunological synapse formation axon guidance optic nerve morphogenesis central nervous system projection neuron axonogenesis retinal ganglion cell axon guidance ephrin receptor signaling pathway camera-type eye morphogenesis positive regulation of synapse assembly dendritic spine morphogenesis angiogenesis skeletal muscle satellite cell activation cranial nerve development neurogenesis establishment of cell polarity detection of temperature stimulus involved in sensory perception of pain cell chemotaxis neural precursor cell proliferation negative regulation of skeletal muscle satellite cell proliferation negative regulation of satellite cell differentiation modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2047 270190 Ensembl ENSG00000154928 ENSMUSG00000032537 UniProt P54762 Q8CBF3 RefSeq (mRNA) NM_004441 NM_001168296 NM_173447 RefSeq (protein) NP_004432 NP_001161768 NP_775623 Location (UCSC) Chr 3: 134.8 – 135.26 Mb Chr 9: 101.8 – 102.23 Mb PubMed search [3] [4]
Wikidata
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Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.^[5][6]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[6]

Interactions

EPH receptor B1 has been shown to interact with:

• ACP1^[7]
• GRB7^[8] and
• NCK1^[9]
• Ephrin-B2^[10]

References

Further reading

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