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Kembali ke Ensiklopedia Arsip Wikipedia Indonesia NS-398 NS-398 NS-398 Names Preferred IUPAC name N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide Identifiers CAS Number 123653-11-2 Y 3D model (JSmol) Interactive image ChEBI CHEBI:73458 Y ChEMBL ChEMBL7162 ChemSpider 4393 Y DrugBank DB14060 IUPHAR/BPS 8976 PubChem CID 4553 CompTox Dashboard (EPA) DTXSID8041084 InChI InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3 YKey: KTDZCOWXCWUPEO-UHFFFAOYSA-N NInChI=1/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3Key: KTDZCOWXCWUPEO-UHFFFAOYAY SMILES CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2 Properties Chemical formula C13H18N2O5S Molar mass 314.36 g·mol−1 Appearance Off-white solid Solubility in water Insoluble Solubility in DMSO 5 mg/mL Hazards GHS labelling:[1] Pictograms Signal word Warning Hazard statements H302, H312, H332 Precautionary statements P280 Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references Chemical compound NS-398 is a COX-2 inhibitor used in the study of the function of cyclooxygenases.[2] See also Celecoxib Tilmacoxib (JTE-522) References ↑ "N194 NS-398". Sigma-Aldrich. Retrieved 13 December 2021. ↑ Wei Shen; Yong Li; Ying Tang; James Cummins; Johnny Huard (2005). "NS-398, a Cyclooxygenase-2-Specific Inhibitor, Delays Skeletal Muscle Healing by Decreasing Regeneration and Promoting Fibrosis". American Journal of Pathology. 167 (4): 1105–1117. doi:10.1016/S0002-9440(10)61199-6. PMC 1603662. PMID 16192645. vteProstanoid signaling modulatorsReceptor(ligands)DP (D2)Tooltip Prostaglandin D2 receptorDP1Tooltip Prostaglandin D2 receptor 1 Agonists: Prostaglandin D2 Treprostinil Antagonists: Asapiprant Laropiprant Vidupiprant DP2Tooltip Prostaglandin D2 receptor 2 Agonists: Indometacin Prostaglandin D2 Antagonists: ADC-3680 AZD-1981 Bay U3405 Fevipiprant MK-1029 MK-7246 QAV-680 Ramatroban Setipiprant Timapiprant TM30089 Vidupiprant EP (E2)Tooltip Prostaglandin E2 receptorEP1Tooltip Prostaglandin EP1 receptor Agonists: Beraprost Enprostil Iloprost (ciloprost) Latanoprost Lubiprostone Misoprostol Prostaglandin E1 (alprostadil) Prostaglandin E2 (dinoprostone) Sulprostone Antagonists: AH-6809 ONO-8130 SC-19220 SC-51089 SC-51322 EP2Tooltip Prostaglandin EP2 receptor Agonists: Butaprost Misoprostol Prostaglandin E1 (alprostadil) Prostaglandin E2 (dinoprostone) Treprostinil Antagonists: AH-6809 PF-04418948 TG 4-155 EP3Tooltip Prostaglandin EP3 receptor Agonists: Beraprost Carbacyclin Cicaprost Enprostil Iloprost (ciloprost) Isocarbacyclin Latanoprost Misoprostol Prostaglandin D2 Prostaglandin E1 (alprostadil) Prostaglandin E2 (dinoprostone) Remiprostol Ricinoleic acid Sulprostone Antagonists: L-798106 EP4Tooltip Prostaglandin EP4 receptor Agonists: Lubiprostone Misoprostol Prostaglandin E1 (alprostadil) Prostaglandin E2 (dinoprostone) TCS-2510 Antagonists: Grapiprant GW-627368 L-161982 ONO-AE3-208 Unsorted Agonists: 16,16-Dimethyl Prostaglandin E2 Aganepag Carboprost Evatanepag Gemeprost Nocloprost Omidenepag Prostaglandin F2α (dinoprost) Simenepag Taprenepag FP (F2α)Tooltip Prostaglandin F receptor Agonists: Alfaprostol Bimatoprost Carboprost Cloprostenol Enprostil Fluprostenol Latanoprost Prostaglandin D2 Prostaglandin F2α (dinoprost) Sulotroban Tafluprost Travoprost Unoprostone IP (I2)Tooltip Prostacyclin receptor Agonists: ACT-333679 AFP-07 Beraprost BMY-45778 Carbacyclin Cicaprost Iloprost (ciloprost) Isocarbacyclin MRE-269 NS-304 Prostacyclin (prostaglandin I2, epoprostenol) Prostaglandin E1 (alprostadil) Ralinepag Selexipag Taprostene TRA-418 Treprostinil Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE 13-APA AA-2414 Argatroban Bay U3405 BMS-180,291 Daltroban Domitroban EP-045 GR-32191 ICI-185282 ICI-192605 Ifetroban Imitrodast L-655240 L-670596 Linotroban Mipitroban ONO-3708 ONO-11120 Picotamide Pinane thromboxane A2 Ramatroban Ridogrel S-145 Samixogrel Seratrodast SQ-28,668 SQ-29,548 Sulotroban Terbogrel Terutroban TRA-418 Unsorted Arbaprostil Ataprost Ciprostene Clinprost Cobiprostone Delprostenate Deprostil Dimoxaprost Doxaprost Ecraprost Eganoprost Enisoprost Eptaloprost Esuberaprost Etiproston Fenprostalene Flunoprost Froxiprost Lanproston Limaprost Luprostiol Meteneprost Mexiprostil Naxaprostene Nileprost Nocloprost Ornoprostil Oxoprostol Penprostene Pimilprost Piriprost Posaraprost Prostalene Rioprostil Rivenprost Rosaprostol Spiriprostil Tiaprost Tilsuprost Tiprostanide Trimoprostil Viprostol Enzyme(inhibitors)COX(PTGS) Salicylic acids: Aloxiprin Aspirin (acetylsalicylic acid) Benorilate (benorylate) Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Mesalazine (5-aminosalicylic acid) Methyl salicylate Salacetamide Salicin Salicylamide Salicylate (salicylic acid) Salsalate Sodium salicylate Triflusal; Acetic acids: Aceclofenac Acemetacin Aclofenac Amfenac Alclofenac Bendazac Bromfenac Bufexamac Bumadizone Cinmetacin Clometacin Diclofenac Difenpiramide Etodolac Felbinac Fenclofenac Fentiazac Glucametacin Indometacin (indomethacin) Indometacin farnesil Ketorolac Lonazolac Mofezolac Nabumetone Oxametacin Oxindanac Proglumetacin Sulindac Sulindac sulfide Tolmetin Zidometacin Zomepirac; Propionic acids: Alminoprofen Benoxaprofen Bucloxic acid (blucloxate) Butibufen Carprofen Dexibuprofen Dexindoprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen Ibuproxam Indoprofen Ketoprofen Loxoprofen Miroprofen Naproxen Naproxcinod Oxaprozin Pirprofen Pranoprofen Suprofen Tarenflurbil Tepoxalin Tiaprofenic acid (tiaprofenate) Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate) Floctafenic acid (floctafenate) Flufenamic acid (flufenamate) Meclofenamic acid (meclofenamate) Mefenamic acid (mefenamate) Morniflumic acid (morniflumate) Niflumic acid (niflumate) Talinflumic acid (talinflumate) Tolfenamic acid (tolfenamate); Pyrazolones: Azapropazone Dipyrone Isopyrin Oxyphenbutazone Phenylbutazone; Enolic acids (oxicams): Ampiroxicam Droxicam Enolicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam; 4-Aminoquinolines: Antrafenine Floctafenine Glafenine; Quinazolines: Fluproquazone Proquazone; Aminonicotinic acids: Clonixeril Clonixin Flunixin; Sulfonanilides: Flosulide Nimesulide; Aminophenols (anilines): Acetanilide AM-404 (N-arachidonoylaminophenol) Bucetin Paracetamol (acetaminophen) Parapropamol Phenacetin Propacetamol; Selective COX-2 inhibitors (coxibs): Apricoxib Celecoxib Cimicoxib Deracoxib Etoricoxib Firocoxib Lumiracoxib Mavacoxib Parecoxib Polmacoxib Robenacoxib Rofecoxib Tilmacoxib Valdecoxib; Others/unsorted: Anitrazafen Clobuzarit Curcumin DuP-697 FK-3311 Flumizole FR-122047 Glimepiride Hyperforin Itazigrel L-655240 L-670596 Licofelone Menatetrenone (vitamin K2) NCX-466 NCX-4040 NS-398 Pamicogrel Resveratrol Romazarit Rosmarinic acid Rutecarpine Satigrel SC-236 SC-560 SC-58125 Tenidap Tiflamizole Timegadine Trifenagrel Tropesin PGD2STooltip Prostaglandin D synthase Retinoids Selenium (selenium tetrachloride, sodium selenite, selenium disulfide) PGESTooltip Prostaglandin E synthaseHQL-79PGFSTooltip Prostaglandin F synthaseBimatoprostPGI2STooltip Prostacyclin synthaseTranylcypromineTXASTooltip Thromboxane A synthase Camonagrel Dazmegrel Dazoxiben Furegrelate Isbogrel Midazogrel Nafagrel Nicogrelate Ozagrel Picotamide Pirmagrel Ridogrel Rolafagrel Samixogrel Terbogrel U63557A Others Precursors: Linoleic acid γ-Linolenic acid (gamolenic acid) Dihomo-γ-linolenic acid Diacylglycerol Arachidonic acid Prostaglandin G2 Prostaglandin H2 See also Receptor/signaling modulators Leukotriene signaling modulators This article about an Ether is a stub. 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