XAP044

Identifiers
IUPAC name 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
CAS Number	196928-50-4 Y
PubChem CID	5428913
IUPHAR/BPS	8545
ChemSpider	4558326
Chemical and physical data
Formula	C15H9IO4
Molar mass	380.137 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
InChI InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H Key:XXZKJJYWINSUMJ-UHFFFAOYSA-N

XAP044 is a drug which acts as a potent and selective antagonist of the metabotropic glutamate receptor 7 (mGluR₇). It inhibits long-term potentiation in the amygdala and inhibits responses associated with stress and anxiety in animal models,^[1] as well as being used to study the role of mGluR₇ in various other processes.^[2][3][4]

References

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