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Kembali ke Ensiklopedia Arsip Wikipedia Indonesia ADX-47273 ADX-47273Chemical compound Pharmaceutical compoundADX-47273Identifiers IUPAC name (S)-(4-fluorophenyl)-(3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]piperidin-1-yl)methanone CAS Number851881-60-2 Y 851881-59-9 (R isomer),837413-22-6 (racemate)PubChem CID11383075IUPHAR/BPS1420ChemSpider9557988 YUNII4C4P7L0W63ChEMBLChEMBL381055 YCompTox Dashboard (EPA)DTXSID80234386 Chemical and physical dataFormulaC20H17F2N3O2Molar mass369.372 g·mol−13D model (JSmol)Interactive image SMILES FC1=CC=C(C(N2CCC[C@@H](C2)C3=NC(C4=CC=C(F)C=C4)=NO3)=O)C=C1 InChI InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1 YKey:VXQCCZHCFBHTTD-HNNXBMFYSA-N Y (verify) ADX-47273 is a research pharmaceutical developed by Addex Therapeutics which acts as a positive allosteric modulator (PAM) selective for the metabotropic glutamate receptor subtype mGluR5.[1][2] It has nootropic and antipsychotic effects in animal studies,[3] and has been used as a lead compound to develop improved derivatives.[4] See also Dipraglurant Raseglurant References ↑ de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ (June 2006). "Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes". Journal of Medicinal Chemistry. 49 (11): 3332–44. doi:10.1021/jm051252j. PMID 16722652. ↑ Stauffer SR (17 August 2011). "Progress toward Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5 (mGlu5)". ACS Chemical Neuroscience. 2 (8): 450–470. doi:10.1021/cn2000519. PMC 3369763. PMID 22860171. ↑ Liu F, Grauer S, Kelley C, Navarra R, Graf R, Zhang G, Atkinson PJ, Popiolek M, Wantuch C, Khawaja X, Smith D, Olsen M, Kouranova E, Lai M, Pruthi F, Pulicicchio C, Day M, Gilbert A, Pausch MH, Brandon NJ, Beyer CE, Comery TA, Logue S, Rosenzweig-Lipson S, Marquis KL (December 2008). "ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities". The Journal of Pharmacology and Experimental Therapeutics. 327 (3): 827–39. doi:10.1124/jpet.108.136580. PMID 18753411. S2CID 19362501. ↑ Engers DW, Rodriguez AL, Williams R, Hammond AS, Venable D, Oluwatola O, Sulikowski GA, Conn PJ, Lindsley CW (April 2009). "Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273". ChemMedChem. 4 (4): 505–11. doi:10.1002/cmdc.200800357. PMC 2865690. PMID 19197923. vteMetabotropic glutamate receptor modulatorsGroup ImGluR1Tooltip Metabotropic glutamate receptor 1 Agonists: ACPD DHPG Glutamate Ibotenic acid Quisqualic acid Ro01-6128 Ro67-4853 Ro67-7476 VU-71 Theanine Antagonists: BAY 36-7620 CPCCOEt Cyclothiazide LY-367,385 LY-456,236 MCPG NPS-2390 mGluR5Tooltip Metabotropic glutamate receptor 5 Agonists: ACPD ADX-47273 CDPPB CHPG DFB DHPG Glutamate Ibotenic acid Quisqualic acid VU-1545; Positive allosteric modulators: LSN2463359 Antagonists: CTEP DMeOB LY-344,545 Mavoglurant MCPG NPS-2390 Remeglurant SIB-1757 SIB-1893; Negative allosteric modulators: AZD9272 Basimglurant Dipraglurant Fenobam GRN-529 MPEP MTEP Raseglurant Group IImGluR2Tooltip Metabotropic glutamate receptor 2 Agonists: BINA CBiPES DCG-IV Eglumetad (LY-354740) Glutamate Ibotenic acid LY-379,268 LY-487,379 LY-566,332 MGS-0028 Pomaglumetad (LY-404039) Pomaglumetad methionil (LY-2140023) Talaglumetad (LY-544344); Positive allosteric modulators: JNJ-40411813 (ADX-71149) Antagonists: APICA CECXG EGLU HYDIA LY-307,452 LY-341,495 MCPG MGS-0039 PCCG-4; Negative allosteric modulators: Decoglurant RO4491533 mGluR3Tooltip Metabotropic glutamate receptor 3 Agonists: CBiPES DCG-IV Eglumetad (LY-354740) Glutamate Ibotenic acid LY-379,268 LY-487,379 MGS-0028 Pomaglumetad (LY-404039) Pomaglumetad methionil (LY-2140023) Talaglumetad (LY-544344) Antagonists: APICA CECXG EGLU HYDIA LY-307,452 LY-341,495 MCPG MGS-0039; Negative allosteric modulators: Decoglurant RO4491533 Group IIImGluR4Tooltip Metabotropic glutamate receptor 4 Agonists: Glutamate L-AP4 LSP2-9166 PHCCC VU-001,171 VU-0155,041; Positive allosteric modulators: Foliglurax MPEP Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112 mGluR6Tooltip Metabotropic glutamate receptor 6 Agonists: Glutamate L-AP4 Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112 mGluR7Tooltip Metabotropic glutamate receptor 7 Agonists: AMN082 Glutamate L-AP4 LSP2-9166 Antagonists: CPPG MAP4 MMPIP MPPG MSOP MTPG UBP-1112 XAP044; Negative allosteric modulators: ADX71743 mGluR8Tooltip Metabotropic glutamate receptor 8 Agonists: DCPG Glutamate L-AP4; Positive allosteric modulators: AZ12216052 Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112 See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators This drug article relating to the nervous system is a stub. 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