LSN2463359

Names
IUPAC name N-Propan-2-yl-5-(2-pyridin-4-ylethynyl)pyridine-2-carboxamide
Identifiers
CAS Number	1401031-52-4 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2431212
ChemSpider	30835751.html : 30835751
EC Number	802-759-0
IUPHAR/BPS	6394
PubChem CID	72551298
CompTox Dashboard (EPA)	DTXSID601166641
InChI InChI=1S/C16H15N3O/c1-12(2)19-16(20)15-6-5-14(11-18-15)4-3-13-7-9-17-10-8-13/h5-12H,1-2H3,(H,19,20) Key: STAFRSGTRKNXHF-UHFFFAOYSA-N
SMILES CC(C)NC(=O)C1=NC=C(C=C1)C#CC2=CC=NC=C2
Properties
Chemical formula	C16H15N3O
Molar mass	265.316 g·mol−1
Hazards
GHS labelling:[1]
Pictograms
Signal word	Warning
Hazard statements	H302, H315, H319, H335
Precautionary statements	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

LSN2463359 is a drug used in scientific research.

Mechanism of action

LSN2463359 is a positive allosteric modulator of the mGluR₅,^[2] which means it increases the activity of glutamate (an excitatory neurotransmitter) at this receptor.

Potential uses

A study has found that LSN2463359 and similar drugs can be used as a treatment to some aspects of cognitive deficits in schizophrenia.^[3] Another study also mention that it could be used in the treatment of schizophrenia due to the potential interactions between NMDA receptors and mGluR₅.^[4]

References