Pitof began his career in the film industry in 1976 as an assistant director, still photographer and film editor. He then branched out into musical scoring, software design and graphic design for televisions, music videos and commercials. Co-founder of Duran Duboi, a digital postproduction company, Pitof worked on commercials, videos and feature films.
In 1997, Pitof took on the role of second unit director for Jean-Pierre Jeunet’s Alien: Resurrection. It was Pitof’s third collaboration with Jeunet after working together on the Jeunet-Caro films Delicatessen and The City of Lost Children.
In 2004, Pitof made his English-language debut with the Hollywood film Catwoman, starring Halle Berry and Sharon Stone.[2] The film was critically panned,[3][4] and is considered one of the worst movies of all time. Pitof was awarded the Razzie Award for Worst Director for the film.[5] In 2024 Pitof openly explained the many issues behind Catwoman and the exclusion of the Batman character.[6]
Pitof was set to direct the US-Chinese co-production Empires of the Deep although he eventually dropped out.[7][8]
In 2019 Pitof co-founded 6th Sense VR, a company developing, producing and distributing VR content.