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Kembali ke Ensiklopedia Arsip Wikipedia Indonesia Topiroxostat TopiroxostatChemical compound Pharmaceutical compoundTopiroxostatClinical dataTrade namesTopiloric, UriadecATC codeNoneLegal statusLegal status Approved in Japan Identifiers IUPAC name 4-[5-(4-Pyridinyl)-1H-1,2,4-triazol-3-yl]-2-pyridinecarbonitrile CAS Number577778-58-6PubChem CID5288320ChemSpider4450517UNII0J877412JVCompTox Dashboard (EPA)DTXSID80206462 Chemical and physical dataFormulaC13H8N6Molar mass248.249 g·mol−13D model (JSmol)Interactive image SMILES C1=CN=CC=C1C2=NC(=NN2)C3=CC(=NC=C3)C#N InChI InChI=1S/C13H8N6/c14-8-11-7-10(3-6-16-11)13-17-12(18-19-13)9-1-4-15-5-2-9/h1-7H,(H,17,18,19)Key:UBVZQGOVTLIHLH-UHFFFAOYSA-N Topiroxostat (INN; trade names Topiloric, Uriadec) is a drug for the treatment of gout and hyperuricemia.[1] It was approved for use in Japan in June 2013.[1] Topiroxostat is a xanthine oxidase inhibitor which reduces serum urate levels.[2] References 1 2 New Drugs FY2013 (PDF), Pharmaceuticals and Medical Devices Agency, Japan, archived from the original (PDF) on 2014-02-22 ↑ Hosoya T, Ohno I, Nomura S, Hisatome I, Uchida S, Fujimori S, et al. (December 2014). "Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout". Clinical and Experimental Nephrology. 18 (6): 876–84. doi:10.1007/s10157-014-0935-8. PMC 4271138. PMID 24448692. vteDrugs used for gout (M04)Uricosuricsprimary Probenecid Sulfinpyrazone Benzbromarone Isobromindione Lesinurad‡ Dotinurad secondary Amlodipine Atorvastatin Fenofibrate Guaifenesin Losartan Xanthine oxidase inhibitorspurine analogues Allopurinol# Oxypurinol Tisopurine other Febuxostat Inositols (Phytic acid Myo-inositol) Topiroxostat Mitotic inhibitors Colchicine Other Cinchophen NSAIDs except aspirin Sevelamer Urate oxidase (Rasburicase Pegloticase) #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III vtePurine receptor modulatorsReceptor(ligands)P0 (adenine) Agonists: 8-Aminoadenine Adenine P1(adenosine) Agonists: 2-(1-Hexynyl)-N-methyladenosine 2-Cl-IB-MECA 2-Chloroadenosine 2'-MeCCPA 4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil 5'-N-ethylcarboxamidoadenosine Adenosine ADP AMP Apadenoson ATL-146e ATP BAY 60–6583 Binodenoson Capadenoson CGS-21680 CP-532,903 CV-1808 Evodenoson GR 79236 HENECA LUF-5835 LUF-5845 N6-Cyclopentyladenosine Namodenoson NECA Neladenoson dalanate Piclidenoson Regadenoson SDZ WAG 994 Selodenoson Sonedenoson Tecadenoson Trabodenoson UK-432,097 YZG-331 Antagonists: 3-Chlorostyrylcaffeine (CSC) 7-Methylxanthine 8-Chlorotheophylline 8-Phenyl-1,3-dipropylxanthine 8-Phenyltheophylline Acefylline Aminophylline ATL-444 AZD-4635 Bamifylline Cafedrine Caffeine Caffeine citrate Cartazolate CGH-2466 CGS-15943 Choline theophyllinate Ciforadenant CPX CVT-6883 Dimethazan DMPX DPCPX Dyphylline Enprofylline Etazolate Etrumadenant Fenethylline IBMX Imaradenant Inupadenant ISAM-140 ISAM-R316 Isovaleric acid Istradefylline KF-26777 Lu AA41063 Lu AA47070 MRE3008F20 MRS-1191 MRS-1220 MRS-1334 MRS-1523 MRS-1706 MRS-1754 MRS-3777 MSX-2 MSX-3 MSX-4 Muvadenant Paraxanthine Pentoxifylline Preladenant Propentofylline Proxyphylline PSB-10 PSB-11 PSB-36 PSB-603 PSB-788 PSB-1115 PSB-1901 Reversine Rolofylline SCH-442,416 SCH-58261 Sipagladenant Taminadenant Theacrine Theobromine Theodrenaline Theophylline Tozadenant Tracazolate Vipadenant VUF-5574 ZM-241,385 P2(nucleotide)P2X(ATPTooltip Adenosine triphosphate) Agonists: 2-Me-SATP α,β-Me-ATP Adenosine ADP AMP Ap4A Ap5A ATP ATPγS BzATP Cibacron blue CTP D-β,γ-Me-ATP GTP HT-AMP Ivermectin L-β,γ-Me-ATP MRS-2219 PAPET-ATP UTP Zinc Antagonists: 5-BDBD A-317491 A-438079 A-740003 A-804598 A-839977 AF-353 AZ-10606120 AZ-11645373 BBG Calcium Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159 NF-023 NF-110 NF-157 NF-279 NF-449 Opiranserin (VVZ-149) Oxidized-ATP Phenol Red Phenolphthalein PPADS PPNDS PSB-12062 Puerarin (Radix puerariae) Purotoxin 1 RB-2 Ro 0437626 Ro 51 RO-3 Sodium ferulate (Angelica sinensis, Ligusticum wallichii) Suramin TC-P 262 Tetramethylpyrazine (ligustrazine) (Ligusticum wallichii) TNP-ATP Zinc P2Y Agonists: 2-Me-SADP 2-Me-SATP 2-Thio-UTP 5-Br-UDP 5-OMe-UDP α,β-Me-ATP Adenosine ADP ADPβS Ap3A AR-C 67085MX ATP ATPγS CTP dATP Denufosol Diquafosol IDP ITP INS-365 INS-37217 MRS-2365 MRS-2690 MRS-2693 MRS-2768 MRS-2957 MRS-4062 NF-546 PAPET-ATP PSB-0474 PSB-1114 UDP UDPβS UDP-galactose UDP-glucose UDP-N-acetylglucosamine Up3U UTP UTPγS Antagonists: 2-Me-SAMP A3P5PS AMPαS Ap4A AR-C 66096 AR-C 67085MX AR-C 69931MX AR-C 118925XX ATP BzATP C1330-7 Cangrelor Clopidogrel Elinogrel Ip5I MRS-2179 MRS-2211 MRS-2279 MRS-2395 MRS-2500 MRS-2578 NF-157 NF-340 PIT PPADS Prasugrel PSB-0739 RB-2 Regrelor Suramin Ticagrelor Ticlopidine UDP Transporter(blockers)CNTsTooltip Concentrative nucleoside transporters 6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone ENTsTooltip Equilibrative nucleoside transporters Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline PMATTooltip Plasma membrane monoamine transporter Decynium-22 Enzyme(inhibitors)XOTooltip Xanthine oxidase Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat Others Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others Others Precursors: Adenine Adenosine AMP ADP ATP Cytosine Cytidine CMP CDP CTP Guanine Guanosine GMP GDP GTP Hypoxanthine Inosine IMP IDP ITP Ribose Uracil Uridine UMP UDP UTP Others: Chrysophanol (rhubarb) See also: Receptor/signaling modulators This drug article relating to the musculoskeletal system is a stub. 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