Piceatannol is the organic compound with the formula ((HO)2C6H3)2CH)2. It can be classified as a stilbenoid, a phenol, and a polyphenol. It is a white solid, although samples often are yellow owing to impurities. The chemical structure of piceatannol was established as being an analog of resveratrol.[1]
Piceatannol is a metabolite of resveratrol found in red wine, grapes, passion fruit, white tea, and Japanese knotweed.[6]Astringin, a piceatannol glucoside, is also found in red wine. The formation of piceatannol from resveratrol is catalyzed by cytochrome P450.[7]
Biochemistry
Piceattanol acts as an inhibitor of the tyrosine kinase Syk and some related tyrosine kinases.[8] In the early 2000s, this prompted research interest in piceatannol and its effect on immune or inflammatory diseases.[9]
↑Cunningham, Jill; Haslam, E.; Haworth, R. D. (1963). "535. The constitution of piceatannol". Journal of the Chemical Society (Resumed): 2875. doi:10.1039/JR9630002875.
↑Matsumoto, Y.; Katano, Y. (2021). "Cardiovascular Protective Effects of Polyphenols Contained in Passion Fruit Seeds Namely Piceatannol and Scirpusin B: A Review". The Tokai Journal of Experimental and Clinical Medicine. 46 (3): 151–161. PMID34498252.
↑Swanson-Mungerson M, Ikeda M, Lev L, Longnecker R, Portis T (2003). "Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases". J. Antimicrob. Chemother. 52 (2): 152–4. doi:10.1093/jac/dkg306. PMID12837743.
