Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1gene.[5][6][7]
Function
This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[7]
Clinical significance
Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.[7]
↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T, etal. (Jun 1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenetics and Cell Genetics. 70 (1–2): 52–54. doi:10.1159/000133990. PMID7736789.
Morton SM, Veile RA, Helms C, Lee M, Kuo WL, Gray J, etal. (1998). "Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s". Genomics. 46 (3): 491–494. doi:10.1006/geno.1997.5051. PMID9441757.
Thomaidou D, Coquillat D, Meintanis S, Noda M, Rougon G, Matsas R (2001). "Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells". Journal of Neurochemistry. 78 (4): 767–778. doi:10.1046/j.1471-4159.2001.00454.x. PMID11520897. S2CID24682985.
Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, etal. (2002). "A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions". Nature Genetics. 32 (3): 411–414. doi:10.1038/ng1004. PMID12355066. S2CID19800079.
Wang V, Davis DA, Haque M, Huang LE, Yarchoan R (2005). "Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells". Cancer Research. 65 (8): 3299–3306. doi:10.1158/0008-5472.CAN-04-4130. PMID15833863.
