Class of chemical compounds in which a phenyl group is directly attached to piperidine
Chemical structure of 4-phenylpiperidine.
Phenylpiperidines are chemical compounds with a phenyl moiety directly attached to piperidine. Of particular interest are a variety of derivatives of 4-phenylpiperidine, which have pharmacological effects including morphine-like activity[1] or other central nervous system effects.
- ↑ Ar denotes an aryl group; here specifically being benzodioxol-3-yl.
Some of the butyrophenone antipsychotics, including aceperone, bromperidol, haloperidol, moperone, and trifluperidol, as well as the related diphenylbutylpiperidine antipsychotic penfluridol, are also 4-phenylpiperidine derivatives.
Certain other opioids, including alvimopan, loperamide, and diphenoxylate, are 4-phenylpiperidine derivatives as well.
