Benzomorphan
Benzomorphan
Names
IUPAC name
6,7-Benzomorphan
Other names
1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine< 10-Azatricyclo[7.3.1.0~2,7~]trideca-2,4,6-triene
Identifiers
ChemSpider
UNII
InChI=1S/C12H15N/c1-2-4-12-9(3-1)7-11-8-10(12)5-6-13-11/h1-4,10-11,13H,5-8H2
N Key:
NSLKFRGZLUIUKO-UHFFFAOYSA-N
N InChI=1/C12H15N/c1-2-4-12-9(3-1)7-11-8-10(12)5-6-13-11/h1-4,10-11,13H,5-8H2
Key: NSLKFRGZLUIUKO-UHFFFAOYAF
Properties
C 12 H 15 N
Molar mass g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25
°C [77
°F], 100
kPa).
Chemical compound
Benzomorphan is a chemical compound that is the base for a series of drugs which variably act on the sigma receptors and κ-opioid receptors , including the following compounds:
Some of these agents are used as analgesics , including pentazocine , phenazocine , dezocine , and eptazocine .[ 7] [ 8]
References
↑ Yokoyama, Naokata; Almaula, Prabodh I.; Block, Fred B.; Granat, Frank R.; Gottfried, Norman; Hill, Ronald T.; McMahon, Elihu H.; Munch, Walter F.; Rachlin, Howard (1979). "Syntheses, analgetic activity and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives" Journal of Medicinal Chemistry . 22 (5): 537– 553. doi :10.1021/jm00191a016 . PMID 37335 . ↑ Yokoyama, Naokata; Block, Fred B.; Clarke, Frank H. (1970). "1,2,3,4,5,6-Hexahydro-6-phenyl-2,6-methano-3-benzazocines. II" Journal of Medicinal Chemistry . 13 (3): 488– 492. doi :10.1021/jm00297a034 . ↑ Castañer, J.; Paton, D. M. (1978). "ID-1229" Drugs of the Future . 3 (4): 298. doi :10.1358/dof.1978.003.04.65215 . ISSN 0377-8282 . Retrieved 21 October 2025 . ↑ Yamamoto H, Saito C, Inaba S, Inukai T, Kobayashi K (May 1975). "The synthesis and pharmacology of a new analgesic, ID-1229". Arzneimittel-Forschung . 25 (5): 795– 801. doi :10.1002/chin.197534266 . PMID 1242327 . ↑ Yamamoto, H, Saito, C, Inaba, S, Inukai, T, Kobayashi, K, Fukumaru, T, Koga, Y, Homma, T, Asami, Y (26 August 1975). "ChemInform Abstract: THE SYNTHESIS AND PHARMACOLOGY OF A NEW ANALGESIC, ID-1229" Chemischer Informationsdienst . 6 (34) chin.197534266. doi :10.1002/chin.197534266 . ISSN 0009-2975 . PMID 1242327 . Retrieved 21 October 2025 . ↑ Parenti, Carmela; Turnaturi, Rita; Aricò, Giuseppina; Marrazzo, Agostino; Prezzavento, Orazio; Ronsisvalle, Simone; Scoto, Giovanna M.; Ronsisvalle, Giuseppe; Pasquinucci, Lorella (2012). "Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand". Life Sciences . 90 (25– 26): 957– 961. doi :10.1016/j.lfs.2012.04.041 . PMID 22580287 . ↑ Kar, Ashutosh (2005). Medicinal Chemistry ISBN 978-81-224-1565-0 ↑ Cittern PA, Kapoor VK, Parfitt RT (October 1986). "Preparation and analgesic activity of (−)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines". Journal of Medicinal Chemistry . 29 (10): 1929– 33. doi :10.1021/jm00160a022 . PMID 2876100 .
