Fletazepam[1] is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is mainly notable for its strong muscle relaxant properties.[2]
Fletazepam is most closely related to other N-trifluoroethyl substituted benzodiazepines such as halazepam and quazepam.[3]
↑DE 2106175,Steinmann, Martin,"Neue 1-Polyfluoralkylbenzodiazepine und Verfahren zu ihrer Herstellung [Novel 1-polyfluoroalkylbenzodiazepines and processes for their preparation]",published 1971-09-30, assigned to Sherico Ltd.
↑Barnett A, Goldstein J, Fiedler EP, Taber RI (November 1974). "The pharmacology of fletazepam a centrally-acting muscle relaxant". Archives Internationales de Pharmacodynamie et de Therapie. 212 (1): 164–74. PMID4476200.
↑Iorio LC, Barnett A, Billard W (July 1984). "Selective affinity of 1-N-trifluoroethyl benzodiazepines for cerebellar type 1 receptor sites". Life Sciences. 35 (1): 105–13. doi:10.1016/0024-3205(84)90157-7. PMID6738302.
