CX1739

Clinical data
Other names	CX-1739
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name N-methyl-N-(oxan-4-yl)-2,1,3-benzoxadiazole-5-carboxamide
CAS Number	1086377-48-1
PubChem CID	25104045
ChemSpider	103868867
UNII	UPB5G360MA
Chemical and physical data
Formula	C13H15N3O3
Molar mass	261.281 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C1CCOCC1)C(=O)C2=CC3=NON=C3C=C2
InChI InChI=1S/C13H15N3O3/c1-16(10-4-6-18-7-5-10)13(17)9-2-3-11-12(8-9)15-19-14-11/h2-3,8,10H,4-7H2,1H3 Key:IRYRMRDDVXULFG-UHFFFAOYSA-N

CX1739 is an investigational new drug developed by Cortex Pharmaceuticals that is being evaluated for the treatment of a wide range of conditions such ADHD,^[1] autism,^[2] opioid-induced respiratory depression,^[3][4] and central sleep apnea.^[5] It is a positive allosteric modulator of the AMPA receptor (ampakine).

CX1739 has similar pharmacological effects and favorable safety profile to older "Type II" ampakines such as CX516 and CX717, but with higher potency and improved bioavailability, unlike "Type I" ampakines such as CX614 which have been found to produce neurotoxicity at high doses.^[6]

As with related ampakine compounds CX1739 has nootropic (memory enhancment) effects,^[1] and was originally investigated for applications such as treatment of ADHD and dementia, but in the course of testing it was found to be effective as a respiratory stimulant and for facilitating nerve repair, so recent research has focused on potential use for conditions such as sleep apnoea and recovery from spinal cord injury.^[7][8]

See also

• AMPA receptor positive allosteric modulator

References

Further reading