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Kembali ke Ensiklopedia Arsip Wikipedia Indonesia BHF-177 BHF-177Chemical compound Pharmaceutical compoundBHF-177Identifiers IUPAC name N-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl]-2-methyl-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinamine CAS Number917896-43-6 YIUPHAR/BPS5503ChemSpider26286940 YUNII73Q4TVR90SCompTox Dashboard (EPA)DTXSID701028428 Chemical and physical dataFormulaC19H20F3N3Molar mass347.385 g·mol−13D model (JSmol)Interactive image SMILES Cc3nc(N[C@@H]2C[C@H]1CC[C@@H]2C1)c(cn3)c4ccc(cc4)C(F)(F)F InChI InChI=1S/C19H20F3N3/c1-11-23-10-16(13-4-6-15(7-5-13)19(20,21)22)18(24-11)25-17-9-12-2-3-14(17)8-12/h4-7,10,12,14,17H,2-3,8-9H2,1H3,(H,23,24,25)/t12-,14+,17+/m0/s1 YKey:ADHZHPOKTRHZGT-DXCKQFNASA-N Y (verify) BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It was shown to reduce self-administration of nicotine in animal studies.[2] References ↑ Guery S, Floersheim P, Kaupmann K, Froestl W (November 2007). "Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors". Bioorganic & Medicinal Chemistry Letters. 17 (22): 6206–11. doi:10.1016/j.bmcl.2007.09.023. PMC 2278029. PMID 17884493. ↑ Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A (July 2008). "Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats". The Journal of Pharmacology and Experimental Therapeutics. 326 (1): 306–14. doi:10.1124/jpet.108.139204. PMC 2574924. PMID 18445779. vteGABA receptor modulatorsIonotropicGABAATooltip γ-Aminobutyric acid A receptor Agonists: 4-AHP (+)-Catechin Bamaluzole Barbiturates (e.g., phenobarbital) Beta-Alanine BL-1020 DAVA DH-P4S Dihydromuscimol GABA Gabamide GABOB Gaboxadol (THIP) Homotaurine (tramiprosate, 3-APS) IAA (IMA) Ibotenic acid iso-THAZ Isoguvacine Isonipecotic acid Kojic amine L-838,417 Lignans (e.g., honokiol) Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org 20599 PF-6372865 Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide ZAPA Positive modulators (abridged; see here for a full list): α-EMTBL Alcohols (e.g., drinking alcohol, 2M2B) Anabolic steroids Avermectins (e.g., ivermectin) Barbiturates (e.g., phenobarbital) Benzodiazepines (e.g., diazepam) Bromide compounds (e.g., potassium bromide) Carbamates (e.g., meprobamate) Carbamazepine Chloralose Chlormezanone Clomethiazole Dihydroergolines (e.g., ergoloid (dihydroergotoxine)) Etazepine Etifoxine Fenamates (e.g., mefenamic acid) Flavonoids (e.g., apigenin, hispidulin) Fluoxetine Flupirtine Imidazoles (e.g., etomidate) Kava constituents (e.g., kavain) Lanthanum Loreclezole Monastrol Neuroactive steroids (e.g., allopregnanolone, cholesterol, THDOC) Niacin Niacinamide Nonbenzodiazepines (e.g., β-carbolines (e.g., abecarnil), cyclopyrrolones (e.g., zopiclone), imidazopyridines (e.g., zolpidem), pyrazolopyrimidines (e.g., zaleplon)) Norfluoxetine Petrichloral Phenols (e.g., propofol) Phenytoin Piperidinediones (e.g., glutethimide) Propanidid Pyrazolopyridines (e.g., etazolate) Quinazolinones (e.g., methaqualone) Retigabine (ezogabine) ROD-188 Skullcap constituents (e.g., baicalin) Stiripentol Sulfonylalkanes (e.g., sulfonmethane (sulfonal)) Topiramate Valerian constituents (e.g., valerenic acid) Volatiles/gases (e.g., chloral hydrate, chloroform, diethyl ether, paraldehyde, sevoflurane) Antagonists: Bicuculline Coriamyrtin Dihydrosecurinine Famiraprinium Gabazine (SR-95531) Hydrastine Hyenanchin (mellitoxin) Iso-THIP PHP-501 Pitrazepin Securinine Sinomenine SR-42641 THAZ Thio-4-PIOL Thio-THIP Thiocolchicoside Tutin Negative modulators: 1,3M1B 3M2B 11-Ketoprogesterone 17-Phenylandrostenol α3IA α5IA (LS-193,268) β-CCB β-CCE β-CCM β-CCP β-EMGBL Anabolic steroids Amiloride Anisatin β-Lactams (e.g., penicillins, cephalosporins, carbapenems) Basmisanil Bemegride Bicyclic phosphates (TBPS, TBPO, IPTBO) BIDN Bilobalide Bupleurotoxin Bupropion CHEB Chlorophenylsilatrane Cicutoxin Cloflubicyne Cyclothiazide DHEA DHEA-S Dieldrin (+)-DMBB DMCM DMPC EBOB Etbicyphat FG-7142 (ZK-31906) Fiproles (e.g., fipronil) Flavonoids (e.g., amentoflavone, oroxylin A) Flumazenil Fluoroquinolones (e.g., ciprofloxacin) Flurothyl Furosemide Golexanolone Iomazenil (123I) IPTBO Isopregnanolone (sepranolone) L-655,708 Laudanosine Lindane MaxiPost Morphine Morphine-3-glucuronide MRK-016 Naloxone Naltrexone Nicardipine Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603 RO4882224 RO4938581 Sarmazenil SCS Suritozole TB-21007 TBOB TBPS TCS-1105 Terbequinil TETS Thujone U-93631 Zinc ZK-93426 GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor Agonists: BL-1020 CACA CAMP Homohypotaurine GABA GABOB Ibotenic acid Isoguvacine Muscimol N4-Chloroacetylcytosine arabinoside Picamilon Progabide TACA TAMP Thiomuscimol Tolgabide Positive modulators: Allopregnanolone Alphaxolone ATHDOC Lanthanides Antagonists: (S)-2-MeGABA (S)-4-ACPBPA (S)-4-ACPCA 2-MeTACA 3-APMPA 4-ACPAM 4-GBA cis-3-ACPBPA Aza-THIP CGP-36742 (SGS-742) DAVA Gabazine (SR-95531) Gaboxadol (THIP) I4AA Iso-THIP Isonipecotic acid Loreclezole P4MPA P4S SKF-97541 SR-95318 SR-95813 THAZ Thio-THIP TPMPA trans-3-ACPBPA ZAPA Negative modulators: 5α-Dihydroprogesterone Bilobalide Loreclezole Picrotoxin (picrotin, picrotoxinin) Pregnanolone ROD-188 THDOC Zinc MetabotropicGABABTooltip γ-Aminobutyric acid B receptor Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL Isovaline JZP-386 Lesogaberan Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Valiloxybate (XW-10172) Positive modulators: ADX-71441 ASP-8062 BHF-177 BHFF rac-BHFF BSPP CGP-7930 CGP-13501 GS-39783 INDV-1000 KK-92A Antagonists: 2-Hydroxysaclofen CGP-35348 CGP-36742 CGP-46381 CGP-52432 CGP-54626 CGP-55845 CGP-64213 DAVA Homotaurine (tramiprosate, 3-APS) Phaclofen Saclofen SCH-50911 Negative modulators: Compound 14 See also Receptor/signaling modulators GABAA receptor positive modulators GABA metabolism/transport modulators This drug article relating to the nervous system is a stub. 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