Member of the German Parliament, 2021–present
In parliament, Mayer has been serving on the Committee on Food and Agriculture.
In addition to her committee assignments, Mayer has been one of the founding members of a cross-party group promoting a One Health approach since 2022.[7]
In February 2026, two weeks before the 2026 Baden-Württemberg state election, Zoe Mayer posted an outtake from a 2018 interview with a regional TV station on TikTok and Instagram featuring Manuel Hagel, then CDU secretary general and now candidate for Minister-President in the upcoming election and accused him for sexualizing underage girls in it.[8] The Greens candidate for the same election, Cem Özdemir defended Hagel and stated that Mayer did act on her own and not on behalf of the Green party.[9][10]