ENSIKLOPEDIA Cari Tekan Enter untuk memulai pencarian cepat. Kembali ke Ensiklopedia Arsip Wikipedia Indonesia Zardaverine Zardaverine Zardaverine Names IUPAC name 3-[4-(Difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one Identifiers CAS Number 101975-10-4 Y 3D model (JSmol) Interactive image ChemSpider 5521 PubChem CID 5723 UNII TQ358GWH6Y Y CompTox Dashboard (EPA) DTXSID8042559 InChI InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)Key: HJMQDJPMQIHLPB-UHFFFAOYSA-N SMILES COC1=C(C=CC(=C1)C2=NNC(=O)C=C2)OC(F)F Properties Chemical formula C12H10F2N2O3 Molar mass 268.220 g·mol−1 Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references Chemical compound Zardaverine is a dual-selective PDE3/4 phosphodiesterase inhibitor.[1] Studies in vitro suggest that it may have useful anti-cancer properties.[2] References ↑ Kümmerle, AE; Schmitt, M; Cardozo, SV; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H; Martins, MA; Fraga, CA; Bourguignon, JJ; Barreiro, EJ (2012). "Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors". Journal of Medicinal Chemistry. 55 (17): 7525–45. doi:10.1021/jm300514y. PMID 22891752. ↑ Corsello, SM; Nagari, RT; Spangler, RD; Rossen, J; Kocak, M; Bryan, JG; Humeidi, R; Peck, D; Wu, X; Tang, AA; Wang, VM; Bender, SA; Lemire, E; Narayan, R; Montgomery, P; Ben-David, U; Garvie, CW; Chen, Y; Rees, MG; Lyons, NJ; McFarland, JM; Wong, BT; Wang, L; Dumont, N; o'Hearn, PJ; Stefan, E; Doench, JG; Harrington, CN; Greulich, H; Meyerson, M (2020). "Discovering the anticancer potential of non-oncology drugs by systematic viability profiling". Nature Cancer. 1 (2): 235–248. doi:10.1038/s43018-019-0018-6. PMC 7328899. PMID 32613204. vtePhosphodiesterase inhibitorsPDE1 MMPX SCH-51866 Vinpocetine PDE2 BAY 60-7550 Carbazeran EHNA Oxindole PDP PDE3 Adibendan Amrinone (inamrinone) Anagrelide Benafentrine Bucladesine Carbazeran Cilostamide Cilostazol Enoximone Ensifentrine Imazodan KMUP-1 Meribendan Milrinone Olprinone Parogrelil Pimobendan Pumafentrine Quazinone RPL-554 Siguazodan Trequinsin Vesnarinone Zardaverine PDE4 Apremilast Arofylline Atizoram Benafentrine Catramilast CC-1088 CDP-840 CGH-2466 Cilomilast Cipamfylline Crisaborole Denbutylline Difamilast Drotaverine Ensifentrine Etazolate Filaminast Glaucine HT-0712 ICI-63197 Indimilast Irsogladine Lavamilast Lirimilast Lotamilast Luteolin Mesembrenone Mesembrine Mesopram Oglemilast Piclamilast Pumafentrine Revamilast Ro 20-1724 Roflumilast Rolipram Ronomilast RPL-554 RS-25344 Tetomilast Tofimilast YM-976 Zardaverine PDE5 Acetildenafil Aildenafil Avanafil Beminafil Benzamidenafil Dasantafil Icariin Gisadenafil Homosildenafil Lodenafil Mirodenafil MY-5445 Nitrosoprodenafil Norcarbodenafil SCH-51866 Sildenafil Sulfoaildenafil T-0156 Tadalafil Udenafil Vardenafil PDE7 BRL-50481 PDE9 BAY 73-6691 PF-04447943 Paraxanthine PDE10 Balipodect Mardepodect MK-8189 Papaverine TC-E 5005 Tofisopam PDE11BC11-38Non-selective Aminophylline Caffeine Choline theophyllinate CPX Dipyridamole Doxofylline Enprofylline Ibudilast IBMX Luteolin Pentoxifylline Propentofylline Theobromine Theophylline Zaprinast Unsorted Diazepam Diprophylline DPCPX Furafylline Lisofylline MDL-12330A Moxaverine Oxagrelate Pentifylline Proxyphylline Quercetin Satigrel Tolafentrine Trapidil See also: Receptor/signaling modulators This article about an organic compound is a stub. You can help Wikipedia by adding missing information.vte
