A UFC Women's Flyweight Championship bout between then champion Nicco Montaño and former UFC Women's Bantamweight Championship title challenger Valentina Shevchenko was expected to take place at the event, as the co-headliner.[6] However, before the weigh-ins, Montaño was transported to a hospital due to the effects of weight cutting and the title bout with Shevchenko was cancelled.[7] Later that day, UFC president Dana White announced that Montaño was stripped of the title and that Shevchenko will fight for the vacant belt "as soon as she's able".[8]
Ryan Benoit was scheduled to face Roberto Sanchez at the event. However, Benoit pulled out of the fight in late August for undisclosed reasons and was replaced by Jarred Brooks.[11]