After previously serving as Chief Product Officer, Dohmke became CEO of Github in November 2021, replacing former CEO Nat Friedman.[7] He served as CEO until 2025.[8]
In August 2025, he announced his leave from CEO of GitHub at the end of the year to start a new company.[2][9] In early 2026 Dohmke announced the launch of the new startup, called Entire.[10] The company produces tools to merge human and AI-based programming. By February 2026 Entire was valued at $300 million.[11]