After the installation of Communist rule, Bughici served as an Ambassador of Romania to Soviet Union in 1949–1952. In July 1952, he was appointed Minister of Foreign Affairs of Romania, replacing Ana Pauker, who was sacked by the communist leadership aided by Joseph Stalin.[5][6] The appointment of Bughici disassociated Pauker's downfall from the anti-Semitism widely seen in Eastern Europe at the time.[7] Bughici served as minister until October 1955. During his political career, he also served as the Vice Prime Minister of Romania.[8] Other offices that he held were that of head of Centrocoop, Minister of the Food Industry and vice president of the Communist Party Control Commission (Colegiul Central de Partid) (1969–1974).[9][10] He served as a deputy in the Great National Assembly for several constituencies from 1948 to 1975.[3]