PROSITE's uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity. Properties from well-studied genes can be propagated to biologically related organisms, and for different or poorly known genes biochemical functions can be predicted from similarities. PROSITE offers tools for protein sequence analysis and motif detection (see sequence motif, PROSITE patterns). It is part of the ExPASyproteomics analysis servers.
The database ProRule builds on the domain descriptions of PROSITE.[3] It provides additional information about functionally or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, substrate- or co-factor-binding sites, posttranslational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.
Statistics
As of 26February2022[update], release 2022_01 has 1,902 documentation entries, 1,311 patterns, 1,336 profiles, and 1,352 ProRules.
See also
Uniprot– the universal protein database, a central resource on protein information – PROSITE adds data to it.
InterPro– a centralized database, grouping data from databases of protein families, domains and functional sites – part of the data come from PROSITE.
