Neuronal calcium sensor Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc.[ 1] EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.[ 2]
Members of NCS family
KCNIP1 ,
KCNIP2 ,
Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein),
KCNIP4
References
↑ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling" . Nat. Rev. Neurosci . 8 (3): 182– 193. doi :10.1038/nrn2093 . PMC 1887812 PMID 17311005 . ↑ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci . 27 (4): 203– 9. doi :10.1016/j.tins.2004.01.010 . PMID 15046879 . S2CID 24156457 . ↑ Weiss JL, Hui H, Burgoyne RD (2010). "Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth" . Cell. Mol. Neurobiol . 30 (8): 1283– 92. doi :10.1007/s10571-010-9588-7 . PMC 11498851 PMID 21104311 . S2CID 2270302 . ↑ Tsvetkov, PO; Roman, AY; Baksheeva, VE; Nazipova, AA; Shevelyova, MP; Vladimirov, VI; Buyanova, MF; Zinchenko, DV; Zamyatnin AA, Jr; Devred, F; Golovin, AV; Permyakov, SE; Zernii, EY (2018). "Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding" . Frontiers in Molecular Neuroscience . 11 : 459. doi :10.3389/fnmol.2018.00459 PMC 6302015 PMID 30618610 .
