Walker played two seasons at Azusa Pacific University before transferring to Fresno State. In 2019, he had 91 tackles, 11.5 tackles for loss and 5 pass deflections.[1] Walker finished his two seasons at Fresno State with 182 tackles including 22.5 tackles for a loss, 10 pass defenses and 6.5 sacks. Walker was named a two-time First-team All-Mountain West Conference selection, along with being named the Defensive MVP during the 2018 Mountain West Conference Football Championship Game.[2][3] Walker ran the 40-yard dash in 4.65 seconds.[1]
On October 30, 2023, Walker signed with the practice squad of the Pittsburgh Steelers.[11] On November 18, he was signed to the Steelers' active roster.[12]
Washington Commanders
On April 2, 2024, Walker signed with the Washington Commanders.[13] Over 17 games, he finished the 2024 regular season with 21 tackles and one fumble recovery.[14]
Arizona Cardinals
On March 13, 2025, Walker signed a one-year contract with the Arizona Cardinals.[15] He was released on August 26 as part of final roster cuts.[16]
New York Jets
On September 1, 2025, Walker was signed to the New York Jets' practice squad.[17] On October 4, he was signed to the active roster.[18]
On March 13, 2026, Walker re-signed with the Jets on a one-year, $1.4 million contract.[19][20]
Personal life
Mykal Walker has a twin brother Malyk. Their father, Michael, played for the Fresno State Bulldogs football team and subsequently joined the New England Patriots, but never played at the NFL level. Michael died of colon cancer in 2012.[21] Mykal Walker's first child, a son, was born in December 2021.[22][23] His cousin is former NFL football running-back Maurice Jones-Drew.