Methyl-MMDA-2 was first synthesized by Alexander Shulgin and was described in his book PiHKAL (Phenethylamines I Have Known and Loved). He states that it is essentially inactive at a dose of 70mg orally, and he did not test higher doses;[1] however, Methyl-MMDA-2 is still likely to be active, perhaps in the 125 to 250 mg range.[citation needed] This reduction in hallucinogenic activity relative to MMDA-2 parallels that of MDA and MDMA, indicating that with phenethylamines, N-methylation substantially reduces 5-HT2A receptoraffinity.[1][2]
