Ewing was born in Lockney, Texas, where he was the eldest surviving child of a large farm family. He won a scholarship to attend Rice University, earning a BA with honors in 1926. He completed his graduate studies at the same institution, earning an MA in 1927 and being awarded his PhD in 1931. In 1928 he was married to Avarilla Hildenbrand, and the couple had a son. The couple divorced in 1941.[7]
Ewing worked as an instructor at the Rice Institute while pursuing his PhD before joining the faculty at Lehigh University in 1930, where he served until 1944.[8] While at Lehigh, he was instrumental in initiating a program in geophysics. In 1944 he married Margaret Sloan Kidder, with whom he had four children.[9]
He divorced a second time, and married his third wife Harriet Greene Bassett in 1965. In 1972 he joined the University of Texas Medical Branch at Galveston, and was named the head of the Division of Earth and Planetary Sciences of the Marine Biomedical Institute.
The seismometer readings from the impact made by the Apollo 17 Saturn S-IVB stage when it struck the lunar surface are viewed in the ALSEP room in the Mission Control Center at Houston by Maurice Ewing, 1972
During his career he published over 340 scientific papers. He served as president of the American Geophysical Union and the Seismological Society of America. He led over 50 oceanic expeditions. He made many contributions to oceanography, including the discovery of the SOFAR Channel, the invention of the sofar bomb, and did much fundamental work on plate tectonics. While he was working on SOFAR, Ewing engaged in deep water photography, partly as a hobby and partly to help the government identify lost ships destroyed by U-boats.[10] He was the chief scientist on board the Glomar Challenger. He originated Project Mogul, an early program to detect Soviet nuclear weapons tests.