Kepentingan penelitian Wheelis termasuk sejarah perang biologis.[1] Ia turut menulis (dengan Larry Gonick) The Cartoon Guide to Genetics (1983). Wheelis memberikan pengetahuan dan teks ilmiah, sementara Gonick kontribusi ilustrasi dan humor.[3]
Karya
Larry Gonick & Mark Wheelis, The Cartoon Guide to Genetics, Longman Higher Education, 1983, 216 pp.
"Biological Warfare before 1914", In: Geissler E, Moon JEvC, editors. Biological and toxin weapons: research, development and use from the Middle Ages to 1945. London: Oxford University Press; 1999. pp 8โ34.