Early career

Prepolec started competing in mixed martial arts professionally in 2008, he fought in regional promotions mostly in Canada and America earning himself a record of 14–5, including a two-fight run in Bellator facing Lance Snow and Jason Fischer at Bellator 64 and Bellator 76 respectively.^[7][8][9] During this time he managed to capture 2 Championships in 2 separate promotions.^[10] Having previously won both the BTC Catchweight Championship(165 lbs) and the TXC Lightweight Championship when he was invited to sign with the Ultimate Fighting Championship in 2019.^[11]

Ultimate Fighting Championship

Making his first walk to the octagon on little more than a week's notice, in a weight class above his fighting weight Kyle Prepolec faced fellow Canadian and UFC veteran of 10 bouts Nordine Taleb in his promotional debut on May 4, 2019, at UFC Fight Night 151.^[12] He lost the fight via unanimous decision.^[13]

Returning to Lightweight Prepolec was next set to faced Austin Hubbard on September 14, 2019, at UFC Fight Night 158.^[14] Prepolec would come out controlling round 1 with his striking staggering his opponent twice, the second round saw more exchanges on the feet. Hubbard took the fight to the ground. Kyle returned to his feet and continued to exchange until the end of the round. Round 3 saw Prepolec attempt a standing guillotine choke and landed a big elbow on the break, after landing a left hand he was taken down and controlled for almost the remainder of the round. Prepolec forced the fight back to the feet with 45 seconds remaining in the fight, landing a left hook and attempting a spinning back fist, he was forced to defend a take down and controlled the rest of the round attempting a modified guillotine choke. Prepolec lost the fight via unanimous decision.^[15]

On March 19, 2020, while nursing an injury Prepolec announced he had been released from the promotion.^[16]

Post-UFC Career

Returning to action after the lockdown in Canada due to COVID-19 Kyle Prepolec faced fellow Canadian Michael Dufort for the inaugural main event of Samuorai 1 for the SMMA Lightweight Championship on November 19, 2021.^[17] He won the bout via split decision, becoming the promotions Inaugural Lightweight Champion.^[18]

Prepolec faced UFC veteran, Shane Campbell on March 4, 2022, at Unified MMA 43, in a Super Lightweight bout. He lost the bout via unanimous decision.^[19]

Prepolec faced Marco Antonio Elpidio on October 22, 2022, at PFC 14. He won the bout by knock out via a head kick in the first round.^[20]

Prepolec faced Josh Henry on April 23, 2023, at PFC 16: Mein vs. Chavez, winning the bout via first-round TKO stoppage after landing a head kick and ground and pound.^[21]

Return to the UFC

Replacing an injured Joel Álvarez and on one week's notice, Prepolec made his return to the UFC against Benoît Saint Denis on May 10, 2025, at UFC 315.^[22] He lost the fight via an arm-triangle choke submission in the second round.^[23]

Prepolec faced Drew Dober on October 18, 2025, at UFC Fight Night 262.^[24] After receiving a low blow that led to a one-point deduction for his opponent, Dober, Prepolec was defeated via technical knockout.^[25] This fight earned him his first Fight of the Night award.^[26]

Mixed martial arts

• Ultimate Fighting Championship
  • Fight of the Night (One time) vs. Drew Dober^[26]
• Samourai MMA
  • SMMA Lightweight Championship
• Triple X Cagefighting
  • TXC Lightweight Champion
• BTC Fight Promotions
  • BTC Catchweight Champion