Bitonio attended Long Beach Wilson High School in Long Beach, California, where he was a three-sport star. He was named to the Press Telegram's Dream Team for football and basketball as a senior. In football, he was a two-time All-league selection and was the Moore League Lineman of the Year. He was a first-team All-conference selection and was named second-team All-state by MaxPreps.com. Bitonio also lettered in track & field as a senior. He led the league in the shot put, recording a top-throw of 15.39 meters at the 2009 CIF Southern Section Division 1 Prelims.[1]
Bitonio was considered one of the top offensive tackle prospects for the 2014 NFL draft.[5][6] He was selected by the Cleveland Browns in the second round (35th overall) of the 2014 NFL draft.[7] He was named to the PFWA All-Rookie Team.[8]
On October 14, 2016, Bitonio was again placed on injured reserve after sustaining a foot injury in Week 5.[10]
On March 9, 2017, Bitonio signed a five-year contract extension with the Browns through the 2022 season.[11][12] He was named to his first Pro Bowl and was named second-team All-Pro after starting all 16 games at left guard.