In 1974, Twitty turned pro. Twitty won three tournaments on the PGA Tour during his career. His best finish in a major tournament was a T-5 at the 1980 PGA Championship.[3] Twitty missed part of the 1996 season due to foot surgery, and now wears sandals with golf spikes while he plays. Twitty played some on the Nationwide Tour in his late forties to prepare for the Senior PGA TOUR. After reaching the age of 50 in 1999, he began play on the senior tour where his best finish was a T-2 at the 2000 Toshiba Senior Classic.