Posner was first known for his pioneering research in organocopper chemistry in which he developed novel methods for organic synthesis involving organocopper reagents.[4][5] He is the author of the textbook An Introduction to Synthesis Using Organocopper Reagents. Posner has also contributed numerous other developments in synthetic organic chemistry including asymmetric synthesis and multicomponent organic reactions.[6] Posner's most recent research was focused on applying organic synthesis to the preparation of novel medicinal agents including isothiocyanates with anticancer properties,[7] new vitamin D analogs for the treatment of psoriasis,[8][9] and new antimalarial peroxides.[10][11][12][13]
Awards
In 1987, Posner was named Maryland Chemist of the Year and in 1994 he received the Distinguished Teaching Award at Johns Hopkins.[3] He was also a 2004 recipient of a Cope Senior Scholar Award from the American Chemical Society.[14]
References
12"GARY H. POSNER". The Robert A. Welch Foundation Research Bulletin (46): 18. 1983.
↑Posner, Gary H.; Canella, Karen A.; Silversmith, Ernest F. (1988). "One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol". Journal of Chemical Sciences. 100 (2–3): 81–90. doi:10.1007/BF02839442. S2CID91965184.
↑Posner, Gary H.; Cho, C.-G.; Green, Julianne V.; Zhang, Yuesheng; Talalay, Paul (1994). "Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes". Journal of Medicinal Chemistry. 37 (1): 170–6. doi:10.1021/jm00027a021. PMID8289191.
↑Guyton, Kathryn Z.; Kensler, Thomas W.; Posner, Gary H. (2004). "Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs". Cancer Chemoprevention. Vol.1. pp.259–274. doi:10.1007/978-1-59259-767-3_17. ISBN978-1-61737-342-8.
↑O'Neill, Paul M.; Posner, Gary H. (2004). "A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides". Journal of Medicinal Chemistry. 47 (12): 2945–2964. doi:10.1021/jm030571c. PMID15163175.
↑Posner, Gary H.; Parker, Michael H.; Northrop, John; Elias, Jeffrey S.; Ploypradith, Poonsakdi; Xie, Suji; Shapiro, Theresa A. (1999). "Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family". Journal of Medicinal Chemistry. 42 (2): 300–304. doi:10.1021/jm980529v. PMID9925735.
↑Posner, Gary H.; Paik, Ik-Hyeon; Chang, Wonsuk; Borstnik, Kristina; Sinishtaj, Sandra; Rosenthal, Andrew S.; Shapiro, Theresa A. (2007). "Malaria-Infected Mice Are Cured by a Single Dose of Novel Artemisinin Derivatives". Journal of Medicinal Chemistry. 50 (10): 2516–9. doi:10.1021/jm070149m. PMID17439113.
Seeman, Jeffrey I. (2016). "Gary H. Posner: Professor, Scientist, Colleague, Role Model, and Friend". Tetrahedron. 72 (40): 5950–5955. doi:10.1016/j.tet.2016.06.053.