FMO2
Identifiers
Aliases	FMO2, FMO1B1, flavin containing monooxygenase 2, flavin containing dimethylaniline monoxygenase 2
External IDs	OMIM: 603955; MGI: 1916776; HomoloGene: 86882; GeneCards: FMO2; OMA:FMO2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.3 Start 171,185,249 bp[1] End 171,212,686 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.1 Start 162,701,886 bp[2] End 162,726,295 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium right lung lower lobe of lung Descending thoracic aorta lactiferous duct ascending aorta vena cava upper lobe of lung upper lobe of left lung abdominal fat Top expressed in lumbar spinal ganglion ascending aorta right lung left lung lobe aortic valve right lung lobe pericardium esophagus right kidney human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity N,N-dimethylaniline monooxygenase activity NADP binding flavin adenine dinucleotide binding monooxygenase activity Cellular component organelle membrane endoplasmic reticulum membrane membrane endoplasmic reticulum intracellular membrane-bounded organelle Biological process xenobiotic metabolic process toxin metabolic process NADPH oxidation NADP metabolic process oxygen metabolic process organic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2327 55990 Ensembl ENSG00000094963 ENSMUSG00000040170 UniProt Q99518 Q8K2I3 RefSeq (mRNA) NM_001301347 NM_001460 NM_001365900 NM_018881 NM_001360913 NM_001360914 RefSeq (protein) NP_001288276 NP_001451 NP_001352829 NP_061369 NP_001347842 NP_001347843 Location (UCSC) Chr 1: 171.19 – 171.21 Mb Chr 1: 162.7 – 162.73 Mb PubMed search [3] [4]
Wikidata
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Flavin-containing monooxygenase 2 (FMO2), also known as dimethylaniline monooxygenase [N-oxide-forming] 2, is a mammalian enzyme that in humans is encoded by the FMO2 gene.^[5][6][7] The gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.^[7]

FMO2 is a member of the family of flavin-containing monooxygenases, NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. It catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate.^[7]

In humans, FMO2 is expressed in lung tissue.^[8] The most common isoform, FMO2*2A, contains a premature stop codon, leading to a truncated protein with no catalytic activity that is probably rapidly degraded.^[7] The other isoform, FMO2*1, present in sub-Saharan Africans (up to 50%), African-Americans (26%) and Hispanics (2–7%), is functional.^[8][9] Its substrates include thioether-containing pesticides, the anti-tuberculosis drug ethionamide, as well as α-naphthylthiourea and other thioureas.^[9]

References

Further reading

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