Ergolina merupakan struktur inti dalam banyak alkaloid dan turunan sintetisnya. Alkaloid ergolina pertama kali dikarakterisasi dalam ergot. Beberapa di antaranya terlibat dalam kondisi ergotisme, yang dapat berupa bentuk kejang[1] atau bentuk gangren. Meskipun demikian, banyak alkaloid ergolina telah ditemukan bermanfaat secara klinis. Produksi tahunan alkaloid ergot di dunia diperkirakan mencapai 5.000–8.000 kg untuk semua ergopeptin, dan 10.000–15.000 kg untuk asam lisergat, yang terutama digunakan dalam pembuatan turunan semisintetis.[2]
↑Schardl CL, Panaccione DG, Tudzynski P (2006). "Ergot alkaloids--biology and molecular biology". The Alkaloids. Chemistry and Biology. 63. Elsevier: 45–86. doi:10.1016/s1099-4831(06)63002-2. ISBN978-0-12-469563-4. PMID17133714. "Clavines are thought to contribute substantially to convulsive ergotism, since C. fusiformis ergots, which possess clavines, but no [lysergic acid] or lysergyl amides, cause convulsive symptoms (26). However, the ergopeptines are known to produce similar symptoms, and are also thought to cause gangrenous ergotism (6). The occurrence of convulsive ergotism without dry gangrene suggests that other clavine or lysergyl alkaloids are involved, or that individual effects of specific ergopeptines may give clinically different syndromes (6)." II. Through the Ages: A History of Ergot Alkaloid Use, Abuse, and Poisoning, p. 50
↑Juszczak GR, Swiergiel AH (2013). "Recreational use of D-lysergamide from the seeds of Argyreia nervosa, Ipomoea tricolor, Ipomoea violacea, and Ipomoea purpurea in Poland". Journal of Psychoactive Drugs. 45 (1): 79–93. doi:10.1080/02791072.2013.763570. PMID23662334. S2CID22086799.
