In 1999, he took on the regular role of identical twins Sundance and Sutch in 38 episodes of science fiction series Thunderstone.[3] He appeared in Hollywood adventure comedy film Kangaroo Jack in 2003.[1] He was then a regular in the series Kick in 2007, playing the role of Nico Angelidis.[3]
In late 2014, Fotiou joined the cast of long-running soap opera Neighbours, in the ten-week role of Dr Nick Petrides, brother of Terese Willis (Rebekah Elmaloglou), who falsely told Paul Robinson (Stefan Dennis) that he had leukaemia.[3] He first appeared on screen in 2015[4] and made his last appearance in 2017. In 2021, he had a recurring role in American science fiction drama series La Brea as Judah.
Fotiou is married to his Head On co-star, Elena Mandalis, with whom he has two sons. The couple run Melbourne drama school, Brave Studios[7][5] and children's drama school Greentree Acting School in Mebourne's Footscray, a sister school to Brave Studios.[1]