Carolin Simon began her career with the GSV Eintracht Baunatal and moved in the summer of 2008 to third division TSV Jahn Calden. On 1 January 2010, she joined the Bundesliga team Hamburger SV[2] for which she made 48 top-flight appearances and scored six goals over the span of two and a half years. After HSV was relegated to the Regionalliga in the summer of 2012, Simon signed with VfL Wolfsburg.[3] However, In Wolfsburg, she appeared in only two DFB Pokal matches, as well as for the second team. In January 2013, the club announced the cancellation of the contract by mutual consent. Shortly thereafter, Simon signed with Bayer 04 Leverkusen until 30 June 2016.[4] In Leverkusen, she was regularly in the starting line-up in the following three and a half years, and in 2015 won the last DFB-Hallenpokal with the team. After expiry of her contract in mid-2016, Simon joined SC Freiburg.[5]