Sample played in 11 games with three starts as a freshman.[4] Sample started 11 games with four sacks in his sophomore season.[5] He was slowed by nagging injuries as a junior but played in all 13 of Tulane's games with 44 total tackles.[6] Sample finished his senior season with 52 tackles, 7.5 tackles for loss and five sacks and was named first-team All-American Athletic Conference.[7]
Sample was selected by the Cincinnati Bengals in the fourth round, 111th overall, of the 2021 NFL draft.[11] He signed his four-year rookie contract with Cincinnati on May 17.[12]
On August 5, 2024, it was announced that Sample had suffered a torn Achilles tendon, ending his season.[13]
Sample re-signed with the Bengals on March 13, 2025.[14]