Paulose was born on 12 June 1914 to the Vicar of Cherai St Mary's Church, Kasheesho Puthusseril Joseph and Eralil Elizabeth of Vadakkan Paravoor. He was named P. J. Paulose and completed his secondary education at Cherai Ramavarma High School. After completing college education at Kottayam CMS College and Alwaye Union Christian College, Paulose joined the Manjinikkara Dayaro. Paulose continued his Syriac education under Rabban Abdul Ahad (later Patriarch Yaqub III).
Holy Orders
Priesthood
In 1934, Yulius Elias, the delegate of the Patriarch to Malankara, ordained Paulose as deacon. In 1938, Yulius ordained him priest at Manjinikkara Dayaro (Monastery). Later Paulose became secretary to Yulius and malphono at Manjinikkara Dayaro.
Metropolitan
On 25 April 1952, the Kandanad diocesan delegates meeting selected 'Kasheesho' Paulose to succeed Athanasius Paulose who had therelinquished his additional duties as the metropolitan of Kandanad due to illness. Patriarch Ignatius Aphrem I Barsoum ordained Paulose P. J. with the name Mor Philoxenus on 19 October 1952 at Homs, Syria.
Catholicos
Catholicos Mor Baselios Paulose II proceeding to the Patriarchal Cathedral, accompanied by Metropolitans, and clergy for the enthronement ceremony of H.H. the Patriarch Zakka-I IwasHis Beatitude Mor Baselios Paulose II, Catholicos of the East leading the enthronement ceremony of the Patriarch of Antioch & all the East, H.H. Mor Ignatius Zakka I Iywas on Sep 14, 1980 at the St.George Cathedral, Damascus, SyriaThe Catholicos of the East His Beatitude Baselios Paulose II, officially announcing the name of the newly elected Patriarch Zakka Iywas in the Episcopal Synod of the Universal Syrian Orthodox Church of Antioch & all the East - 1980
Baselios Paulose II, Malphono Naseeho Fr. Athungal Corepiscopos with K. O. Varghese Kaniyampadikkal
Death and entombment
Went to heavenly abode on 1 September 1996. The remains of Catholicos Basileus Paulose II are interred in a tomb in St. George's Monastery, Malekurish near Puthenkurishu in Ernakulam District, Kerala.