Main was elected Minister of Kirkbean Church in the Presbytery of Dumfries in 1942.[10] He retired from full-time ministry on 13 February 1946 due to ill health.[4][11]
In July 1919, Main was made an Honorary Chaplain in recognition of his war service.[19] On 31 March 1922, he was appointed a Chaplain to the Forces 4th Class in the Royal Army Chaplains' Department, Territorial Army Reserve.[20] While a professor at the University of Glasgow, he served as chaplain to the Glasgow University Officers' Training Corps; he stood down in 1942 when he left academia.[21]