From 1951 to 1953, he was a post-doctoral researcher at the University of Illinois, where he developed his highly cited theory on the transfer of spin polarization; once the theory had been confirmed and demonstrated by other scientists, it became known as the Overhauser effect. He was on the faculty at Cornell University from 1953 to 1958, and then left to join the research staff at Ford Motor Company. Overhauser remained at Ford until 1973, when he joined the faculty at Purdue University. He remained at Purdue as the Stuart Distinguished Professor of Physics for the rest of his career. Overhauser died in 2011 in West Lafayette, Indiana.