Sintase pseudouridin 23S rRNA 1911/1915/1917 Sintase pseudouridin1911/1915/1917 23S rRNA (juga dikenal sebagai RluD )(Templat:EnzExplorer , RluD , pseudouridine synthase RluD ) adalah sebuah enzim dengan nama sistematis 23S rRNA-uridine1911/1915/1917 urasil mutase .[ 1] [ 2] [ 3] [ 4] mengkatalisis reaksi kimia berikut:
23S rRNA uridin1911 /uridin1915 /uridin1917
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1911 /pseudouridin1915 /pseudouridin1917 Nukleotida -nukleotida ini terletak pada heliks-lup 69 yang penting secara fungsional dari 23S rRNA .
Referensi
↑ Leppik M, Peil L, Kipper K, Liiv A, Remme J (November 2007). "Substrate specificity of the pseudouridine synthase RluD in Escherichia coli" . The FEBS Journal . 274 (21): 5759– 66. doi :10.1111/j.1742-4658.2007.06101.x PMID 17937767 . ↑ Ejby M, Sørensen MA, Pedersen S (December 2007). "Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination" . Proceedings of the National Academy of Sciences of the United States of America . 104 (49): 19410– 5. Bibcode :2007PNAS..10419410E . doi :10.1073/pnas.0706558104 PMC 2148303 PMID 18032607 . ↑ Sivaraman J, Iannuzzi P, Cygler M, Matte A (January 2004). "Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli". Journal of Molecular Biology . 335 (1): 87– 101. doi :10.1016/j.jmb.2003.10.003 . PMID 14659742 . ↑ Wrzesinski J, Bakin A, Ofengand J, Lane BG (July 2000). "Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase (RluD)" . IUBMB Life . 50 (1): 33– 7. doi :10.1080/15216540050176566 PMID 11087118 .
