Quattordio borders the following municipalities: Castello di Annone, Cerro Tanaro, Felizzano, Masio, Refrancore, and Viarigi.
Despite its small population, the town has been, for more than 70 years, an important industrial site (particularly with regard to paint industry). The name derives from the LatinQuattuordecimum ("fourteenth"), indicating its distance from Asti.