The Ottawa Hospital Research Institute (OHRI), formerly Ottawa Health Research Institute,[1] is a non-profit academic health research institute located in the city of Ottawa. It was formed in 2001 following the merger of three Ottawa hospitals. The Ottawa Hospital Research Institute is the research arm of The Ottawa Hospital and affiliated with the University of Ottawa.
As of 2022, the Ottawa Hospital Research Institute houses approximately 2,200 scientists, clinician investigators, students, research fellows, and support staff.[2][3] It has five research programs: Cancer Therapeutics; Chronic Disease; Clinical Epidemiology; Regenerative Medicine; and Neurosciences.[4] Its researchers are studying more than a hundred different diseases, conditions and specialties with an overall focus on translating discoveries and knowledge into better health.[2]
David Moher led the development of the CONSORT reporting guidelines for clinical trials and the PRISMA reporting guidelines for systematic reviews and meta-analyses.
Doug Manuel developed ProjectBigLife,[14] a life expectancy calculator that helps educate people about healthy lifestyle choices.
John Bell and his colleagues demonstrated for the first time that an intravenously-delivered viral therapy can selectively infect and spread within tumours in humans.[15]
Dean Fergusson and Paul Hebert discovered that aprotinin is associated with an increased risk of death compared to other drugs routinely used to prevent blood loss during heart surgery.[16]
Annette O'Connor pioneered the use of Patient Decision Aids.[17]
Natasha Kekre is leading the first clinical trial of made-in-Canada CAR-T cells for the treatment of cancer.[18]
