| Judul | Sutradara | Pemeran Terkenal | Genre | Catatan |
| 12 Rounds | Renny Harlin | John Cena, Ashley Scott, Steve Harris, Aidan Gillen, Brian J. White, Taylor Cole | laga, Thriller | Fox Atomic, WWE Studios |
| 17 Again | Burr Steers | Zac Efron, Leslie Mann, Thomas Lennon, Matthew Perry, Michelle Trachtenberg | Comedy, Teen | New Line Cinema |
| (500) Days of Summer | Marc Webb | Joseph Gordon-Levitt, Zooey Deschanel | komedi | rilis tanggal 24 Juli, Fox Searchlight Pictures |
| Adventureland | Greg Mottola | Jesse Eisenberg, Kristen Stewart, Martin Starr, Bill Hader, Kristen Wiig, Margarita Levieva, Ryan Reynolds | Komedi | |
| American Violet | Tim Disney | Nicole Behaire, Tim Blake Nelson, Will Patton, Michael O'Keefe, Xzibit, Charles Dutton, Alfre Woodard | Drama | Samuel Goldwyn Films |
| Americanese | Eric Byler | Chris Tashima, Joan Chen, Allison Sie, Kelly Hu, Ben Shenkman | Drama, Romance | IFC First Take |
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| Angels & Demons | Ron Howard | Tom Hanks, Ayelet Zurer, Ewan McGregor | Adventure, Mystery | Tanggal rilis:15 Mei Columbia Pictures |
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| Assassination of a High School President | Brett Simon | Bruce Willis, Reece Thompson, Mischa Barton, Michael Rappaport, Kathryn Morris | Komedi | |
| Astro Boy | David Bowers | Freddie Highmore, Nicolas Cage, Donald Sutherland, Nathan Lane, Bill Nighy, Eugene Levy, Kristen Bell | Family, Sci-Fi | Animated film, Tanggal rilis: 23 Oktober, Summit Entertainment |
| Bad Lieutenant: Port of Call New Orleans | Werner Herzog | Nicolas Cage, Eva Mendes, Val Kilmer, Xzibit | Crime | |
| The Box | Richard Kelly | Cameron Diaz, James Marsden | Horror | Release date: November 9 |
| Bride Wars | Gary Winick | Kate Hudson, Anne Hathaway | Comedy | |
| The Brothers Bloom | Rian Johnson | Rachel Weisz, Adrien Brody, Rinko Kikuchi, Mark Ruffalo | Comedy, Crime | Release date: May 15 (limited), May 29 (wide). Summit Entertainment |
| Confessions of a Shopaholic | P.J. Hogan | Isla Fisher, Hugh Dancy, Joan Cusack, John Goodman, John Lithgow, Kristin Scott Thomas, Leslie Bibb | Comedy, Romance | |
| Coraline | Henry Selick | Dakota Fanning, Teri Hatcher, Ian McShane, Jennifer Saunders, Keith David, John Hodgman | Fantasy, Sci-Fi | Animated film |
| Crank: High Voltage | Mark Neveldine, Brian Taylor | Jason Statham, Amy Smart, Clifton Collins Jr., Efren Ramirez, Dwight Yoakam, Reno Wilson | laga | |
| Crossing Over | Wayne Kramer | Harrison Ford, Sean Penn, Jim Sturgess, Ashley Judd, Alice Eve, Alice Braga, Cliff Curtis, Summer Bishil, Ray Liotta | drama | |
| Dance Flick | Damien Dante Wayans | Chelsea Makela, Shoshana Bush, Damon Wayans Jr., Essence Atkins, Marlon Wayans, Shawn Wayans, David Alan Grier, Keenan Ivory Wayans, Kim Wayans, Craig Wayans | Comedy, Spoof | Rilis: 22 Mei, Paramount Pictures, MTV Films |
| Dragonball: Evolution | James Wong | Justin Chatwin, Emmy Rossum, Joon Park, Chow Yun-Fat, James Marsters, Eriko Tamura, Jamie Chung, Randall Duk Kim | laga, fantasi | 20th Century Fox |
| Duplicity | Tony Gilroy | Julia Roberts, Clive Owen, Tom Wilkinson, Paul Giamatti | Comedy, Crime, Drama | |
| Earth | Alastair Fothergill | James Earl Jones (narrator) | Adventure, Documentary | Rilis: 22 April. Disneynature |
| Echelon Conspiracy | Greg Marcks | Shane West, Edward Burns, Ving Rhames, Jonathan Pryce, Tamara Feldman | Action, kriminal, Thriller | |
| The Education of Charlie Banks | Fred Durst | Jesse Eisenberg, Jason Ritter, Christopher Marquette, Eva Amurri, Sebastian Stan, Gloria Votsis | drama, remaja | Anchor Bay Entertainment |
| Fanboys | Kyle Newman | Sam Huntington, Christopher Marquette, Dan Fogler, Jay Baruchel, Kristen Bell, Thom Bishops, David Denman, Seth Rogen | komedi | The Weinstein Company |
| Fantastic Mr. Fox | Wes Anderson | Voices: George Clooney, Meryl Streep, Cate Blanchett | | Animated film, Release date: November 9 |
| Fast & Furious | Justin Lin | Vin Diesel, Paul Walker, Michelle Rodriguez, Jordana Brewster | Action thriller | Universal Pictures |
| Fighting | Dito Montiel | Channing Tatum, Terrence Howard | Action, Drama | Release date: April 24, Rogue Pictures |
| Fired Up | Will Gluck | Nick D'Agosto, Eric Christian Olsen, Sarah Roemer, AnnaLynne McCord, Molly Sims, John Michael Higgins | Comedy, Teen | Screen Gems |
| Five Killers | Robert Luketic | Ashton Kutcher, Katherine Heigl | Action thriller | Katalyst Productions, Lionsgate |
| Friday the 13th | Marcus Nispel | Jared Padalecki, Danielle Panabaker, Aaron Yoo, Amanda Righetti, Travis Van Winkle, Derek Mears | Horror | New Line Cinema, Paramount Pictures |
| The Ghost | Roman Polanski | Ewan McGregor, Pierce Brosnan, Olivia Williams, Kim Catrall | Horror | |
| Ghosts of Girlfriends Past | Mark Waters | Matthew McConaughey, Jennifer Garner, Michael Douglas, Breckin Meyer, Lacey Chabert, Emma Stone, Anne Archer, Robert Forster, Amanda Walsh | Fantasy, Romantic comedy | Release date: May 1, New Line Cinema |
| The Great Buck Howard | Sean McGinly | John Malkovich, Colin Hanks, Emily Blunt, Steve Zahn, Tom Hanks | Comedy-drama | Magnolia Pictures |
| The Hangover | Todd Phillips | Bradley Cooper, Ed Helms, Zach Galifianakis, Heather Graham, Justin Bartha | Comedy | Release date: June 5, Warner Bros., Legendary Pictures |
| Hannah Montana: The Movie | Peter Chelsom | Miley Cyrus, Emily Osment, Jason Earles, Melora Hardin, Vanessa Williams, Billy Ray Cyrus | Family | Walt Disney Pictures |
| The Haunting in Connecticut | Peter Cornwell | Virginia Madsen, Kyle Gallner, Martin Donovan, Elias Koteas, Amanda Crew | Horror | Gold Circle Films, Maple Pictures |
| He's Just Not That Into You | Kevin Kwapis | Ben Affleck, Jennifer Aniston, Drew Barrymore, Jennifer Connelly, Kevin Connelly, Bradley Cooper, Ginnifer Goodwin, Scarlett Johansson, Justin Long | Romantic comedy | Based on the self-help book by Greg Behrendt and Liz Tuccillo. New Line Cinema |
| Hotel for Dogs | Thor Freudenthal | Emma Roberts, Jake T. Austin, Kyla Pratt, Don Cheadle, Lisa Kudrow, Kevin Dillon | Comedy, Family | Dreamworks Pictures, Nickelodeon Movies |
| The Human Factor | Clint Eastwood | Morgan Freeman, Matt Damon | | Biopic of Nelson Mandela |
| I Love You, Man | John Hamburg | Paul Rudd, Jason Segel | Comedy | Paramount Pictures |
| The Informant | Steven Soderbergh | Matt Damon | Black comedy, Thriller | Rilis: 18 September |
| The Informers | Gregor Jordan | Billy Bob Thorton, Kim Basinger, Winona Ryder, Mickey Rourke, Jon Foster, Amber Heard, Brad Renfro | Drama | Rilis: 24 April.Film terakhir Brad Renfro. |
| Inglourious Basterds | Quentin Tarrantino | Brad Pitt, Mélanie Laurent, Christoph Waltz, Daniel Brühl, Diane Kruger | War, Western | Rilis: 21 Agustus |
| Inkheart | Iain Softley | Brendan Fraser, Paul Bettany, Helen Mirren, Jim Broadbent, Andy Serkis, Eliza Bennett | Adventure, Keluarga, Fantasi | Alliance Films |
| The International | Tom Tykwer | Clive Owen, Naomi Watts | Laga, Thriller | Columbia Pictures |
| Jonas Brothers: The 3D Concert Experience | Bruce Hendricks | Nick Jonas, Joe Jonas, Kevin Jonas, Demi Lovato, Taylor Swift, Christa B. Allen | konser | Walt Disney Pictures |
| Julie & Julia | | Meryl Streep | | |
| Kane & Lynch | | Bruce Willis, Billy Bob Thorton | | |
| Knowing | Alex Proyas | Nicolas Cage | Sci-Fi | Summit Entertainment |
| The Last House on the Left | Dennis Iliadis | Garrett Dillahunt, Rhys Coiro, Martha MacIsaac, Riki Lindhome, Tony Goldwyn, Monica Potter, Spencer Treat Clark, Sara Paxton | Horror | Rogue Pictures |
| Little Ashes | Paul Morrison | Javier Beltran, Robert Pattinson, Matthew McNulty, Marina Gatell, Arly Jover | Bio-pic, Drama, Romance | Regent Releasing |
| Madea Goes to Jail | Tyler Perry | Tyler Perry, Sofia Vergara, Vanessa Ferlito, Derek Luke, Keshia Knight Pulliam, David Mann, Tamela Mann, Ronreaco Lee, Ion Overman, Viola Davis | Comedy, Drama | Lionsgate |
| The Mercenary: Love and Honor | Randall Wallace | Angelina Jolie | Adventure, Drama | |
| Men | | Tom Cruise | | |
| Miss March | Zach Cregger, Trevor Moore | Zach Cregger, Trevor Moore, Raquel Alessi, Molly Stanton, Craig Robinson | Comedy | Fox Searchlight |
| Monsters vs. Aliens | Rob Letterman, Conrad Vernon | Reese Witherspoon, Seth Rogen, Hugh Laurie, Rainn Wilson, Kiefer Sutherland, Will Arnett, Stephen Colbert, Paul Rudd | Comedy, Sci-Fi | DreamWorks Animation |
| Motherhood | Katherine Dieckmann | Uma Thurman, Minnie Driver, Anthony Edwards | Comedy | |
| My Life in Ruins | Donald Petrie | Nia Vardalos, Richard Dreyfuss | Comedy | Release date: June 5, Fox Searchlight Pictures |
| My Sister's Keeper | Nick Cassavetes | Cameron Diaz, Alec Baldwin, Abigail Breslin, Sofia Vassilieva, Joan Cusack, Thomas Dekker, Jason Patric | Drama | Release date: June 26. Adapted from the novel by Jodi Picoult |
| New in Town | Jonas Elmer | Renée Zellweger, Harry Connick, Jr. | Comedy, Romance | Lionsgate, Gold Circle Films |
| New Moon | Chris Weitz | Kristen Stewart, Robert Pattinson, Taylor Lautner, Ashley Greene, Peter Facinelli, Elizabeth Reaser, Jackson Rathbone, Nikki Reed, Kellan Lutz, Billy Burke, Rachelle Lefèvre, Dakota Fanning, Cameron Bright, Graham Greene | Drama, Romance | Release date: November 20. Based on the book by Stephanie Meyer. Summit Entertainment |
| New York | Kabir Khan | John Abraham, Katrina Kaif, Neil Mukesh, Irrfan Khan | laga, Thriller | 20th Century Fox, YRF Entertainment |
| Night at the Museum: Battle of the Smithsonian | Shawn Levy | Ben Stiller, Dick Van Dyke, Robin Williams, Amy Adams, Hank Azaria, Owen Wilson, Steve Coogan, Jonah Hill, Ricky Gervais | Adventure, Comedy | Based on the book by Milan Trenc |
| Not Easily Broken | Bill Duke | Morris Chestnut, Taraji P. Henson, Kevin Hart, Eddie Cibrian, Jenifer Lewis | Drama | Based on a novel by T.D. Jakes. Screen Gems |
| Notorious | George Tillman Jr. | Jamal Woolard, Derek Luke, Angela Bassett, Anthony Mackie, Naturi Naughton, Antonique Smith | Bio-pic, Drama | Fox Searchlight |
| Observe and Report | Jody Hill | Seth Rogen, Anna Faris, Michael Pena, Ray Liotta | Action, Comedy | Warner Bros. Pictures, Legendary Pictures |
| Obsessed | Steve Shill | Idris Elba, Beyonce Knowles, Ali Larter | Thriller | Release date: April 24, Screen Gems |
| Paul Blart: Mall Cop | Steve Carr | Kevin James, Jayma Mays, Keir O'Donnell, Bobby Cannavale, Stephen Rannazzisi, Shirley Knight | Comedy | |
| Ponyo on the Cliff by the Sea | | Matt Damon | | |
| The Proposal | Anne Fletcher | Ryan Reynolds, Sandra Bullock | Romantic comedy | Rilis: 12 Juni. Touchstone Pictures |
| Public Enemies | Michael Mann | Johnny Depp, Christian Bale, Marion Cotillard, Channing Tatum, David Wenham, Stephen Graham, Giovanni Ribisi, Stephen Dorff, Billy Crudup | Crime drama | Rilis: 1 Juli |
| Push | Paul McGuigan | Chris Evans, Dakota Fanning, Camilla Belle, Djimon Hounsou | Sci-Fi, Thriller | Summit Entertainment, Icon Productions |
| Race to Witch Mountain | Andy Fickman | Dwayne Johnson, AnnaSophia Robb, Carla Gugino, Garry Marshall, Ciaran Hinds, Alexander Ludwig, Tom Everett Scott, Christopher Marquette | keluarga, Sci-Fi | Walt Disney Pictures |
| The Soloist | Joe Wright | Jamie Foxx, Robert Downey, Jr. | Bio-pic, Drama | Release date: April 24, Paramount Pictures, DreamWorks |
| Star Trek | J.J. Abrams | Chris Pine, Zachary Quinto, Karl Urban, Simon Pegg, Zoe Saldana, John Cho, Anton Yelchin, Eric Bana, Leonard Nimoy | Action, Sci-Fi | Rilis:8 Mei Paramount Pictures |
| State of Play | Kevin MacDonald | Russell Crowe, Ben Affleck, Rachel McAdams, Helen Mirren | Crime drama | Universal Pictures |
| The Steam Experiment | Philippe Martinez | Val Kilmer, Armand Assante, Eric Roberts | | |
| Streets of Blood | Charles Winkler | Val Kilmer, 50 Cent, Michael Biehn, Sharon Stone | Action drama | |
| Sunshine Cleaning | Christine Jeffs | Amy Adams, Emily Blunt, Alan Arkin, Steve Zahn, Clifton Collins, Jr. | Comedy, Drama | Overture Films |
| The Surrogates | | Bruce Willis | | |
| Taken | Pierre Morel | Liam Neeson, Maggie Grace, Leland Orser, Jon Gries, David Warshofsky, Katie Cassidy, Holly Valance, Famke Janssen | Action, Drama, Thriller | 20th Century Fox, EuropaCorp |
| The Taking of Pelham 1 2 3 | Tony Scott | Denzel Washington, John Travolta | Action, Crime, Drama | Rilis:12 Juni |
| The Thaw | | Val Kilmer, Martha MacIsaac, Kyle Schmid, Steph Song | Horror, Sci-Fi | |
| Tree of Life | Terrence Malick | Brad Pitt, Sean Penn, Jennifer Sipes | | |
| Transformers: Revenge of the Fallen | Michael Bay | Shia LaBeouf, Megan Fox, Josh Duhamel, Tyrese Gibson, John Turturro, Matthew Marsden | Action, Sci-Fi | Release date: June 26 |
| Two Lovers | James Gray | Joaquin Phoenix, Gwyneth Paltrow, Vinessa Shaw, Isabella Rossellini, Elias Koteas | Romantic drama | Alliance Films, Magnolia Pictures |
| The Ugly Truth | Robert Luketic | Katharine Heigl, Gerard Butler | Romantic comedy | Rilis: 24 Juli |
| The Unborn | David S. Goyer | Odette Yustman, Gary Oldman, Meagan Good, Cam Gigandet, James Remar, Jane Alexander, Idris Elba | horor | Rogue Pictures |
| Underworld: Rise of the Lycans | Patrick Tatopoulos | Rhona Mitra, Michael Sheen, Bill Nighy, Kevin Grevioux, Shane Brolly, Steven Mackintosh | Action, Drama, horor | |
| The Uninvited | Thomas Guard, Charles Guard | Emily Browning, Elizabeth Banks, Arielle Kebbel, David Strathairn | Drama, Horror | DreamWorks SKG |
| Up | Jonas Rivera | Jordan Nagai, Christopher Plummer | | Memenangkan Academy Awards tahun 2010 untuk kategori Film Animasi Terbaik dan Musik Orisinal Terbaik. |
| Up in the Air | Jason Reitman | George Clooney, Anna Kendrick | | Based on novel by Walter Kirn |
| Watchmen | Zack Snyder | Jeffrey Dean Morgan, Matthew Goode, Patrick Wilson, Malin Akerman, Billy Crudup, Jackie Earl Haley | Action, Drama, Mystery | Berdasarkan novel grafik dengan judul yang sama. |
| Winged Creatures | Rowan Woods | Kate Beckinsale, Dakota Fanning, Guy Pearce, Josh Hutcherson, Forest Whitaker, Jennifer Hudson, Jackie Earle Haley, Jeanne Tripplehorn, Embeth Davidtz | Drama, Thriller | |
| X-Men Origins: Wolverine | Gavin Hood | Hugh Jackman | Action adventure | |
| Zuli | Erin Johnson, Hannah Johnson | | Komedi | |
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